ZFPM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007506Biological processgonadal mesoderm development
GO_2000195Biological processnegative regulation of female gonad development
GO_0030324Biological processlung development
GO_0048568Biological processembryonic organ development
GO_0003148Biological processoutflow tract septum morphogenesis
GO_0001701Biological processin utero embryonic development
GO_0060045Biological processpositive regulation of cardiac muscle cell proliferation
GO_0007507Biological processheart development
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0001570Biological processvasculogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030154Biological processcell differentiation
GO_0003221Biological processright ventricular cardiac muscle tissue morphogenesis
GO_0060412Biological processventricular septum morphogenesis
GO_2000020Biological processpositive regulation of male gonad development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0008270Molecular functionzinc ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZFPM2
Protein nameZinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2)
Zinc finger protein, FOG family member 2
Zinc finger protein, multitype 2
SynonymsZNF89B
FOG2
DescriptionFUNCTION: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). .

AccessionsENST00000517361.1
ENST00000407775.7 [Q8WW38-1]
ENST00000520492.5
E5RJX0
E7ET52
Q8WW38
Q32MA5
ENST00000520027.5