NIPBL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	36 studies	40% ± 18%	Explore
natural killer cell	30 studies	28% ± 9%	Explore
fibroblast	27 studies	32% ± 15%	Explore
B cell	26 studies	28% ± 11%	Explore
macrophage	26 studies	38% ± 20%	Explore
pericyte	25 studies	31% ± 16%	Explore
T cell	21 studies	29% ± 11%	Explore
classical monocyte	21 studies	26% ± 10%	Explore
CD8-positive, alpha-beta T cell	20 studies	27% ± 8%	Explore
astrocyte	19 studies	46% ± 20%	Explore
CD4-positive, alpha-beta T cell	19 studies	27% ± 8%	Explore
smooth muscle cell	18 studies	32% ± 13%	Explore
regulatory T cell	18 studies	26% ± 7%	Explore
non-classical monocyte	17 studies	24% ± 10%	Explore
memory B cell	17 studies	23% ± 5%	Explore
naive B cell	16 studies	26% ± 6%	Explore
oligodendrocyte precursor cell	16 studies	46% ± 20%	Explore
microglial cell	16 studies	60% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	30% ± 8%	Explore
ciliated cell	15 studies	33% ± 12%	Explore
oligodendrocyte	15 studies	51% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	28% ± 7%	Explore
gamma-delta T cell	15 studies	27% ± 10%	Explore
mast cell	14 studies	33% ± 13%	Explore
monocyte	14 studies	33% ± 17%	Explore
endothelial cell of lymphatic vessel	14 studies	36% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	25% ± 8%	Explore
mature NK T cell	14 studies	24% ± 9%	Explore
mucosal invariant T cell	14 studies	26% ± 8%	Explore
basal cell	13 studies	38% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	23% ± 7%	Explore
conventional dendritic cell	13 studies	24% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	28% ± 6%	Explore
glutamatergic neuron	12 studies	51% ± 24%	Explore
capillary endothelial cell	12 studies	25% ± 11%	Explore
epithelial cell	12 studies	42% ± 23%	Explore
GABAergic neuron	11 studies	50% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	29% ± 7%	Explore
plasmacytoid dendritic cell	11 studies	28% ± 8%	Explore
type I pneumocyte	10 studies	37% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	23% ± 6%	Explore
dendritic cell	10 studies	43% ± 18%	Explore
myeloid cell	9 studies	42% ± 10%	Explore
adipocyte	9 studies	45% ± 14%	Explore
endothelial cell of artery	9 studies	22% ± 6%	Explore
type II pneumocyte	8 studies	36% ± 15%	Explore
leukocyte	8 studies	45% ± 21%	Explore
neuron	8 studies	45% ± 23%	Explore
myofibroblast cell	8 studies	29% ± 15%	Explore
vein endothelial cell	8 studies	30% ± 19%	Explore
club cell	7 studies	40% ± 14%	Explore
retinal cone cell	7 studies	40% ± 19%	Explore
retinal rod cell	7 studies	40% ± 23%	Explore
endothelial cell of vascular tree	7 studies	31% ± 20%	Explore
respiratory goblet cell	6 studies	41% ± 16%	Explore
interneuron	6 studies	61% ± 20%	Explore
lymphocyte	6 studies	41% ± 22%	Explore
precursor B cell	6 studies	34% ± 9%	Explore
amacrine cell	6 studies	37% ± 17%	Explore
retina horizontal cell	6 studies	41% ± 20%	Explore
mesothelial cell	6 studies	39% ± 15%	Explore
Mueller cell	6 studies	42% ± 22%	Explore
T follicular helper cell	6 studies	22% ± 5%	Explore
innate lymphoid cell	6 studies	28% ± 9%	Explore
connective tissue cell	6 studies	29% ± 10%	Explore
secretory cell	5 studies	24% ± 6%	Explore
abnormal cell	5 studies	33% ± 16%	Explore
glial cell	5 studies	34% ± 10%	Explore
progenitor cell	5 studies	35% ± 14%	Explore
retinal ganglion cell	5 studies	37% ± 22%	Explore
hematopoietic stem cell	5 studies	23% ± 8%	Explore
pro-B cell	5 studies	35% ± 6%	Explore
brush cell	5 studies	27% ± 8%	Explore
cardiac muscle cell	5 studies	45% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	26% ± 8%	Explore
goblet cell	5 studies	37% ± 29%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	27% ± 9%	Explore
hematopoietic precursor cell	4 studies	36% ± 14%	Explore
squamous epithelial cell	4 studies	37% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	43% ± 12%	Explore
granule cell	4 studies	46% ± 3%	Explore
plasma cell	4 studies	40% ± 7%	Explore
immature B cell	4 studies	28% ± 7%	Explore
retinal bipolar neuron	4 studies	38% ± 16%	Explore
retinal pigment epithelial cell	4 studies	43% ± 26%	Explore
mononuclear phagocyte	4 studies	37% ± 12%	Explore
muscle cell	4 studies	38% ± 27%	Explore
neutrophil	4 studies	23% ± 6%	Explore
alveolar macrophage	4 studies	48% ± 20%	Explore
ionocyte	3 studies	33% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	25% ± 3%	Explore
exhausted T cell	3 studies	28% ± 10%	Explore
plasmablast	3 studies	40% ± 12%	Explore
glomerular endothelial cell	3 studies	21% ± 2%	Explore
podocyte	3 studies	30% ± 13%	Explore
renal beta-intercalated cell	3 studies	35% ± 15%	Explore
neural crest cell	3 studies	19% ± 0%	Explore
GABAergic interneuron	3 studies	45% ± 6%	Explore
endocardial cell	3 studies	34% ± 14%	Explore
GABAergic amacrine cell	3 studies	49% ± 16%	Explore
OFF-bipolar cell	3 studies	48% ± 19%	Explore
ON-bipolar cell	3 studies	51% ± 19%	Explore
glycinergic amacrine cell	3 studies	43% ± 11%	Explore
rod bipolar cell	3 studies	47% ± 20%	Explore
erythroblast	3 studies	26% ± 7%	Explore
cholangiocyte	3 studies	59% ± 9%	Explore
hepatocyte	3 studies	63% ± 19%	Explore
ependymal cell	3 studies	55% ± 15%	Explore
enteroendocrine cell	3 studies	25% ± 4%	Explore
adventitial cell	3 studies	29% ± 10%	Explore
erythrocyte	3 studies	54% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 8%	Explore
Schwann cell	3 studies	36% ± 21%	Explore
transit amplifying cell	3 studies	45% ± 36%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	22% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
double negative thymocyte	3 studies	38% ± 11%	Explore
renal principal cell	3 studies	31% ± 13%	Explore
mural cell	3 studies	63% ± 11%	Explore
mucus secreting cell	3 studies	43% ± 7%	Explore
myoepithelial cell	3 studies	36% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	50% ± 21%	Explore
lung	15 studies	29% ± 13%	Explore
peripheral blood	15 studies	27% ± 9%	Explore
eye	8 studies	45% ± 23%	Explore
heart	5 studies	37% ± 11%	Explore
kidney	5 studies	31% ± 9%	Explore
liver	5 studies	35% ± 17%	Explore
bone marrow	4 studies	29% ± 11%	Explore
lymph node	4 studies	20% ± 2%	Explore
intestine	4 studies	22% ± 7%	Explore
adipose	4 studies	40% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4698.17	1445 / 1445	100%	36.77	183 / 183
uterus	100%	6060.45	170 / 170	100%	24.75	459 / 459
breast	100%	5458.97	459 / 459	100%	33.28	1116 / 1118
prostate	100%	4745.42	245 / 245	100%	20.35	501 / 502
ovary	100%	6369.29	180 / 180	100%	16.44	429 / 430
lung	100%	5512.28	578 / 578	100%	27.40	1152 / 1155
thymus	100%	5765.14	653 / 653	100%	24.11	602 / 605
brain	100%	2707.38	2631 / 2642	100%	21.49	702 / 705
pancreas	100%	2598.58	327 / 328	99%	20.73	177 / 178
bladder	100%	4971.86	21 / 21	99%	20.94	498 / 504
adrenal gland	100%	3631.82	258 / 258	99%	14.13	227 / 230
intestine	100%	5099.86	966 / 966	98%	18.86	519 / 527
stomach	100%	3703.80	359 / 359	98%	22.34	281 / 286
kidney	100%	3202.70	89 / 89	97%	17.48	873 / 901
skin	100%	6003.81	1809 / 1809	94%	19.85	444 / 472
liver	100%	1938.00	226 / 226	92%	10.49	373 / 406
adipose	100%	5223.02	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4946.00	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	18.37	29 / 29
muscle	100%	3421.18	803 / 803	0%	0	0 / 0
spleen	100%	5261.66	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	26.90	45 / 45
ureter	0%	0	0 / 0	100%	6.05	1 / 1
heart	99%	2627.39	849 / 861	0%	0	0 / 0
peripheral blood	96%	3926.16	896 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	75%	8.52	60 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0061780	Biological process	mitotic cohesin loading
GO_0048592	Biological process	eye morphogenesis
GO_0007605	Biological process	sensory perception of sound
GO_1990414	Biological process	replication-born double-strand break repair via sister chromatid exchange
GO_0003151	Biological process	outflow tract morphogenesis
GO_0045995	Biological process	regulation of embryonic development
GO_0035261	Biological process	external genitalia morphogenesis
GO_0035136	Biological process	forelimb morphogenesis
GO_0000070	Biological process	mitotic sister chromatid segregation
GO_0007064	Biological process	mitotic sister chromatid cohesion
GO_0061010	Biological process	gallbladder development
GO_0001656	Biological process	metanephros development
GO_0071169	Biological process	establishment of protein localization to chromatin
GO_2001224	Biological process	positive regulation of neuron migration
GO_0006974	Biological process	DNA damage response
GO_0061038	Biological process	uterus morphogenesis
GO_0034087	Biological process	establishment of mitotic sister chromatid cohesion
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0035115	Biological process	embryonic forelimb morphogenesis
GO_0048703	Biological process	embryonic viscerocranium morphogenesis
GO_0034088	Biological process	maintenance of mitotic sister chromatid cohesion
GO_0071481	Biological process	cellular response to X-ray
GO_0048638	Biological process	regulation of developmental growth
GO_0048557	Biological process	embryonic digestive tract morphogenesis
GO_0042634	Biological process	regulation of hair cycle
GO_0048565	Biological process	digestive tract development
GO_0007420	Biological process	brain development
GO_0050890	Biological process	cognition
GO_0048589	Biological process	developmental growth
GO_0008104	Biological process	protein localization
GO_0042471	Biological process	ear morphogenesis
GO_0045778	Biological process	positive regulation of ossification
GO_0060325	Biological process	face morphogenesis
GO_0003007	Biological process	heart morphogenesis
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0045444	Biological process	fat cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0090694	Cellular component	Scc2-Scc4 cohesin loading complex
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0032116	Cellular component	SMC loading complex
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0032039	Cellular component	integrator complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0061775	Molecular function	cohesin loader activity
GO_1990841	Molecular function	promoter-specific chromatin binding
GO_0003682	Molecular function	chromatin binding
GO_0070087	Molecular function	chromo shadow domain binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0042826	Molecular function	histone deacetylase binding
GO_0036033	Molecular function	mediator complex binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NIPBL
Protein name	Nipped-B protein NIPBL cohesin loading factor Nipped-B-like protein (Delangin) (SCC2 homolog) NIPBL protein
Synonyms	SCC2 IDN3
Description	FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin . Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner . Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). .
Accessions	A6QL62 ENST00000282516.13 [Q6KC79-1] Q6KC79 H0Y8M3 A0A590UJS4 Q6IEH8 ENST00000448238.2 [Q6KC79-2] ENST00000513819.1 A2RRA7 ENST00000652901.1

NIPBL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review