KDM5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060763Biological processmammary duct terminal end bud growth
GO_0009791Biological processpost-embryonic development
GO_0060444Biological processbranching involved in mammary gland duct morphogenesis
GO_0010628Biological processpositive regulation of gene expression
GO_0061038Biological processuterus morphogenesis
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0006338Biological processchromatin remodeling
GO_0060992Biological processresponse to fungicide
GO_0006355Biological processregulation of DNA-templated transcription
GO_2000864Biological processregulation of estradiol secretion
GO_0033601Biological processpositive regulation of mammary gland epithelial cell proliferation
GO_0007338Biological processsingle fertilization
GO_0070306Biological processlens fiber cell differentiation
GO_0048511Biological processrhythmic process
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0003676Molecular functionnucleic acid binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0034647Molecular functionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity
GO_0032452Molecular functionhistone demethylase activity
GO_0008270Molecular functionzinc ion binding
GO_0032453Molecular functionhistone H3K4 demethylase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKDM5B
Protein name[histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67)
Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B)
Lysine demethylase 5B
Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_a (Lysine demethylase 5B) (cDNA FLJ16281 fis, clone NT2RI3003104, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA)
SynonymsJARID1B
hCG_2027322
RBBP2H1
PLU1
DescriptionFUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code . Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 . In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). .

AccessionsA0A3B3ITA8
R4GN45
ENST00000648473.1
ENST00000235790.9
A0A3B3IS31
B3KV94
ENST00000649089.1
A0A3B3ITJ7
A0A3B3ISE6
A0A3B3IT51
ENST00000650368.1
ENST00000648354.1
ENST00000602511.1
A0A3B3ITR1
ENST00000650417.1
Q9UGL1
ENST00000367265.9 [Q9UGL1-1]
ENST00000648056.1
A0A3B3IT85
ENST00000649770.1
A0A3B3IT25
A0A3B3ITA9
ENST00000648676.1
A0A3B3ITE7
A0A3B3IS40
A0A3B3ITN3
ENST00000648738.1
ENST00000649200.1
ENST00000650493.1
A0A3B3ISK2
A0A3B3ITR3
A0A3B3ITJ3
ENST00000650569.1
ENST00000648469.1
ENST00000367264.7 [Q9UGL1-2]
ENST00000648338.1
ENST00000649929.1