Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 14 studies | 25% ± 8% | |
astrocyte | 13 studies | 30% ± 11% | |
ciliated cell | 12 studies | 28% ± 10% | |
endothelial cell | 12 studies | 34% ± 15% | |
basal cell | 9 studies | 30% ± 15% | |
neuron | 9 studies | 41% ± 17% | |
smooth muscle cell | 9 studies | 22% ± 6% | |
glutamatergic neuron | 9 studies | 44% ± 24% | |
pericyte | 9 studies | 22% ± 6% | |
type I pneumocyte | 8 studies | 25% ± 9% | |
retinal rod cell | 8 studies | 48% ± 20% | |
oligodendrocyte precursor cell | 8 studies | 26% ± 8% | |
epithelial cell | 8 studies | 43% ± 17% | |
club cell | 8 studies | 28% ± 7% | |
myofibroblast cell | 7 studies | 25% ± 10% | |
GABAergic neuron | 7 studies | 42% ± 17% | |
interneuron | 6 studies | 41% ± 16% | |
hematopoietic stem cell | 6 studies | 27% ± 10% | |
connective tissue cell | 6 studies | 27% ± 12% | |
type II pneumocyte | 6 studies | 24% ± 7% | |
retinal cone cell | 6 studies | 36% ± 8% | |
Mueller cell | 6 studies | 37% ± 14% | |
respiratory goblet cell | 5 studies | 24% ± 6% | |
secretory cell | 5 studies | 24% ± 8% | |
abnormal cell | 5 studies | 25% ± 5% | |
progenitor cell | 5 studies | 27% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 22% ± 3% | |
amacrine cell | 5 studies | 23% ± 6% | |
goblet cell | 5 studies | 35% ± 26% | |
regulatory T cell | 5 studies | 25% ± 6% | |
squamous epithelial cell | 4 studies | 33% ± 23% | |
macrophage | 4 studies | 26% ± 9% | |
microglial cell | 4 studies | 32% ± 16% | |
brush cell | 4 studies | 32% ± 17% | |
retina horizontal cell | 4 studies | 25% ± 7% | |
retinal bipolar neuron | 4 studies | 21% ± 1% | |
mesothelial cell | 4 studies | 26% ± 3% | |
enteroendocrine cell | 4 studies | 24% ± 6% | |
oligodendrocyte | 4 studies | 23% ± 6% | |
hematopoietic precursor cell | 3 studies | 28% ± 8% | |
granule cell | 3 studies | 28% ± 2% | |
precursor B cell | 3 studies | 25% ± 1% | |
capillary endothelial cell | 3 studies | 24% ± 5% | |
GABAergic amacrine cell | 3 studies | 27% ± 5% | |
ON-bipolar cell | 3 studies | 22% ± 9% | |
glycinergic amacrine cell | 3 studies | 23% ± 2% | |
rod bipolar cell | 3 studies | 36% ± 10% | |
T cell | 3 studies | 27% ± 5% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 4% | |
gamma-delta T cell | 3 studies | 28% ± 12% | |
group 3 innate lymphoid cell | 3 studies | 28% ± 5% | |
mucus secreting cell | 3 studies | 24% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4256.98 | 1445 / 1445 | 100% | 18.95 | 183 / 183 |
breast | 100% | 3821.64 | 459 / 459 | 100% | 29.33 | 1116 / 1118 |
prostate | 100% | 4033.71 | 245 / 245 | 100% | 14.29 | 501 / 502 |
lung | 100% | 3787.88 | 578 / 578 | 99% | 17.39 | 1148 / 1155 |
bladder | 100% | 3783.38 | 21 / 21 | 99% | 14.74 | 498 / 504 |
intestine | 100% | 3563.16 | 966 / 966 | 98% | 10.36 | 514 / 527 |
ovary | 100% | 4410.79 | 180 / 180 | 97% | 13.71 | 418 / 430 |
thymus | 100% | 3249.25 | 652 / 653 | 97% | 10.23 | 586 / 605 |
skin | 100% | 7540.69 | 1809 / 1809 | 97% | 14.90 | 456 / 472 |
uterus | 100% | 4423.14 | 170 / 170 | 97% | 16.79 | 443 / 459 |
stomach | 100% | 2552.69 | 359 / 359 | 96% | 10.16 | 274 / 286 |
pancreas | 97% | 1819.43 | 319 / 328 | 98% | 13.06 | 175 / 178 |
brain | 94% | 1931.88 | 2480 / 2642 | 98% | 10.64 | 693 / 705 |
kidney | 100% | 1996.63 | 89 / 89 | 89% | 7.06 | 800 / 901 |
adrenal gland | 100% | 2646.08 | 258 / 258 | 75% | 4.54 | 172 / 230 |
liver | 72% | 763.40 | 162 / 226 | 54% | 3.98 | 221 / 406 |
adipose | 100% | 3186.63 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 2658.26 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.23 | 1 / 1 |
blood vessel | 100% | 2702.90 | 1331 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 2651.32 | 896 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 90% | 6.04 | 72 / 80 |
lymph node | 0% | 0 | 0 / 0 | 90% | 4.54 | 26 / 29 |
tonsil | 0% | 0 | 0 / 0 | 89% | 12.81 | 40 / 45 |
heart | 88% | 1273.74 | 759 / 861 | 0% | 0 | 0 / 0 |
muscle | 70% | 788.27 | 566 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0060763 | Biological process | mammary duct terminal end bud growth |
GO_0009791 | Biological process | post-embryonic development |
GO_0060444 | Biological process | branching involved in mammary gland duct morphogenesis |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0061038 | Biological process | uterus morphogenesis |
GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
GO_0006338 | Biological process | chromatin remodeling |
GO_0060992 | Biological process | response to fungicide |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_2000864 | Biological process | regulation of estradiol secretion |
GO_0033601 | Biological process | positive regulation of mammary gland epithelial cell proliferation |
GO_0007338 | Biological process | single fertilization |
GO_0070306 | Biological process | lens fiber cell differentiation |
GO_0048511 | Biological process | rhythmic process |
GO_0044344 | Biological process | cellular response to fibroblast growth factor stimulus |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0042393 | Molecular function | histone binding |
GO_0003676 | Molecular function | nucleic acid binding |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0034647 | Molecular function | histone H3K4me/H3K4me2/H3K4me3 demethylase activity |
GO_0032452 | Molecular function | histone demethylase activity |
GO_0008270 | Molecular function | zinc ion binding |
GO_0032453 | Molecular function | histone H3K4 demethylase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | KDM5B |
Protein name | [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) Lysine demethylase 5B Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_a (Lysine demethylase 5B) (cDNA FLJ16281 fis, clone NT2RI3003104, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA) |
Synonyms | JARID1B hCG_2027322 RBBP2H1 PLU1 |
Description | FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code . Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 . In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). . |
Accessions | A0A3B3ITA8 R4GN45 ENST00000648473.1 ENST00000235790.9 A0A3B3IS31 B3KV94 ENST00000649089.1 A0A3B3ITJ7 A0A3B3ISE6 A0A3B3IT51 ENST00000650368.1 ENST00000648354.1 ENST00000602511.1 A0A3B3ITR1 ENST00000650417.1 Q9UGL1 ENST00000367265.9 [Q9UGL1-1] ENST00000648056.1 A0A3B3IT85 ENST00000649770.1 A0A3B3IT25 A0A3B3ITA9 ENST00000648676.1 A0A3B3ITE7 A0A3B3IS40 A0A3B3ITN3 ENST00000648738.1 ENST00000649200.1 ENST00000650493.1 A0A3B3ISK2 A0A3B3ITR3 A0A3B3ITJ3 ENST00000650569.1 ENST00000648469.1 ENST00000367264.7 [Q9UGL1-2] ENST00000648338.1 ENST00000649929.1 |