KMT5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043516Biological processregulation of DNA damage response, signal transduction by p53 class mediator
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051301Biological processcell division
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0018026Biological processpeptidyl-lysine monomethylation
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0007076Biological processmitotic chromosome condensation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005700Cellular componentpolytene chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0140939Molecular functionhistone H4 methyltransferase activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0016278Molecular functionlysine N-methyltransferase activity
GO_0140944Molecular functionhistone H4K20 monomethyltransferase activity
GO_0042054Molecular functionhistone methyltransferase activity
GO_0042799Molecular functionhistone H4K20 methyltransferase activity
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0140110Molecular functiontranscription regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKMT5A
Protein nameN-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)
Lysine methyltransferase 5A
[histone H4]-lysine(20) N-methyltransferase (EC 2.1.1.361)
SynonymsPRSET7
SETD8
SET07
SET8
DescriptionFUNCTION: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins . Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) . H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression . Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes . Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis . Involved in chromosome condensation and proper cytokinesis . Nucleosomes are preferred as substrate compared to free histones . Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes . Plays a negative role in TGF-beta response regulation and a positive role in cell migration . .

AccessionsENST00000437502.1
ENST00000402868.8 [Q9NQR1-2]
Q9NQR1
E3VVS3
F8WC45
ENST00000437519.5
C9JKQ0