Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 28% ± 12% | |
microglial cell | 11 studies | 38% ± 13% | |
astrocyte | 10 studies | 28% ± 14% | |
oligodendrocyte precursor cell | 9 studies | 26% ± 12% | |
oligodendrocyte | 9 studies | 29% ± 11% | |
macrophage | 9 studies | 28% ± 11% | |
epithelial cell | 7 studies | 35% ± 17% | |
adipocyte | 7 studies | 23% ± 5% | |
plasmacytoid dendritic cell | 7 studies | 31% ± 7% | |
GABAergic neuron | 6 studies | 34% ± 18% | |
dendritic cell | 6 studies | 30% ± 14% | |
fibroblast | 6 studies | 24% ± 7% | |
myeloid cell | 6 studies | 25% ± 7% | |
endothelial cell of lymphatic vessel | 6 studies | 32% ± 11% | |
natural killer cell | 5 studies | 22% ± 7% | |
monocyte | 5 studies | 25% ± 7% | |
pericyte | 5 studies | 25% ± 6% | |
type I pneumocyte | 5 studies | 22% ± 9% | |
squamous epithelial cell | 4 studies | 34% ± 18% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 19% ± 3% | |
B cell | 4 studies | 23% ± 6% | |
cardiac muscle cell | 4 studies | 18% ± 0% | |
ciliated cell | 4 studies | 23% ± 5% | |
lymphocyte | 4 studies | 27% ± 8% | |
glutamatergic neuron | 4 studies | 52% ± 21% | |
club cell | 4 studies | 23% ± 9% | |
interneuron | 4 studies | 38% ± 19% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 4% | |
plasma cell | 3 studies | 29% ± 2% | |
alveolar macrophage | 3 studies | 35% ± 10% | |
smooth muscle cell | 3 studies | 19% ± 3% | |
type II pneumocyte | 3 studies | 20% ± 5% | |
basal cell | 3 studies | 36% ± 23% | |
goblet cell | 3 studies | 39% ± 26% | |
neuron | 3 studies | 39% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 1202.82 | 180 / 180 | 100% | 24.07 | 430 / 430 |
breast | 100% | 1807.57 | 459 / 459 | 100% | 29.67 | 1117 / 1118 |
lung | 100% | 1301.08 | 577 / 578 | 100% | 28.04 | 1155 / 1155 |
bladder | 100% | 1789.29 | 21 / 21 | 100% | 26.96 | 503 / 504 |
esophagus | 100% | 1721.38 | 1445 / 1445 | 99% | 25.69 | 182 / 183 |
intestine | 100% | 1736.38 | 966 / 966 | 99% | 23.05 | 524 / 527 |
skin | 100% | 2205.82 | 1809 / 1809 | 99% | 38.47 | 469 / 472 |
uterus | 100% | 2172.89 | 170 / 170 | 99% | 26.59 | 455 / 459 |
stomach | 100% | 1136.79 | 359 / 359 | 99% | 21.76 | 283 / 286 |
brain | 99% | 710.96 | 2608 / 2642 | 100% | 29.71 | 705 / 705 |
thymus | 100% | 1190.06 | 652 / 653 | 98% | 18.95 | 595 / 605 |
prostate | 100% | 1157.41 | 245 / 245 | 97% | 13.56 | 485 / 502 |
kidney | 100% | 921.24 | 89 / 89 | 93% | 12.43 | 836 / 901 |
pancreas | 88% | 394.25 | 290 / 328 | 98% | 18.95 | 174 / 178 |
adrenal gland | 100% | 864.56 | 258 / 258 | 86% | 11.81 | 198 / 230 |
liver | 83% | 341.15 | 188 / 226 | 68% | 6.96 | 276 / 406 |
adipose | 100% | 1888.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1834.65 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1596.99 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1326.98 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 25.85 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.72 | 1 / 1 |
lymph node | 0% | 0 | 0 / 0 | 97% | 18.14 | 28 / 29 |
heart | 97% | 802.72 | 831 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 25.25 | 76 / 80 |
peripheral blood | 91% | 982.28 | 845 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0060816 | Biological process | random inactivation of X chromosome |
GO_0007283 | Biological process | spermatogenesis |
GO_0120094 | Biological process | negative regulation of peptidyl-lysine crotonylation |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0007286 | Biological process | spermatid development |
GO_0016607 | Cellular component | nuclear speck |
GO_0005694 | Cellular component | chromosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0035064 | Molecular function | methylated histone binding |
GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0120092 | Molecular function | crotonyl-CoA hydratase activity |
GO_0005515 | Molecular function | protein binding |
GO_0003682 | Molecular function | chromatin binding |
Gene name | CDYL |
Protein name | Chromodomain Y like Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) |
Synonyms | CDYL1 |
Description | FUNCTION: [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) . Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape . Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes . Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression . Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs . Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase . Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation . Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). .; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain . .; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain . Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. . |
Accessions | ENST00000397588.8 [Q9Y232-2] A0A669KAZ7 ENST00000491864.1 ENST00000328908.9 [Q9Y232-1] ENST00000343762.5 [Q9Y232-4] Q9Y232 ENST00000440139.5 C9JQG7 ENST00000449732.6 [Q9Y232-4] |