ATF7IP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	28 studies	31% ± 12%	Explore
natural killer cell	26 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	22 studies	25% ± 8%	Explore
endothelial cell	20 studies	29% ± 12%	Explore
naive B cell	19 studies	32% ± 10%	Explore
memory B cell	18 studies	27% ± 6%	Explore
CD4-positive, alpha-beta T cell	17 studies	26% ± 8%	Explore
astrocyte	16 studies	35% ± 15%	Explore
regulatory T cell	16 studies	25% ± 6%	Explore
T cell	15 studies	29% ± 10%	Explore
macrophage	14 studies	33% ± 15%	Explore
oligodendrocyte	14 studies	35% ± 13%	Explore
oligodendrocyte precursor cell	14 studies	37% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	26% ± 7%	Explore
mature NK T cell	13 studies	23% ± 7%	Explore
gamma-delta T cell	13 studies	27% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	25% ± 6%	Explore
fibroblast	12 studies	26% ± 9%	Explore
microglial cell	11 studies	41% ± 13%	Explore
mucosal invariant T cell	11 studies	27% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	29% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	9 studies	21% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	23% ± 7%	Explore
GABAergic neuron	9 studies	39% ± 19%	Explore
glutamatergic neuron	9 studies	38% ± 23%	Explore
adipocyte	9 studies	35% ± 11%	Explore
pericyte	9 studies	25% ± 9%	Explore
endothelial cell of lymphatic vessel	8 studies	31% ± 13%	Explore
epithelial cell	8 studies	33% ± 16%	Explore
dendritic cell	8 studies	33% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	21% ± 3%	Explore
myeloid cell	7 studies	27% ± 6%	Explore
leukocyte	6 studies	37% ± 18%	Explore
neuron	6 studies	36% ± 18%	Explore
interneuron	6 studies	45% ± 19%	Explore
basal cell	6 studies	30% ± 17%	Explore
club cell	6 studies	24% ± 5%	Explore
retina horizontal cell	6 studies	29% ± 11%	Explore
retinal cone cell	6 studies	27% ± 13%	Explore
monocyte	6 studies	27% ± 7%	Explore
ciliated cell	5 studies	28% ± 9%	Explore
amacrine cell	5 studies	28% ± 16%	Explore
mast cell	5 studies	28% ± 10%	Explore
T follicular helper cell	5 studies	23% ± 6%	Explore
abnormal cell	5 studies	33% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 6%	Explore
smooth muscle cell	5 studies	25% ± 6%	Explore
type II pneumocyte	5 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	27% ± 11%	Explore
plasmablast	4 studies	26% ± 8%	Explore
classical monocyte	4 studies	21% ± 5%	Explore
non-classical monocyte	4 studies	23% ± 6%	Explore
granule cell	4 studies	29% ± 8%	Explore
precursor B cell	4 studies	27% ± 4%	Explore
immature B cell	4 studies	28% ± 6%	Explore
retinal bipolar neuron	4 studies	27% ± 14%	Explore
cardiac muscle cell	4 studies	31% ± 3%	Explore
lymphocyte	4 studies	47% ± 20%	Explore
retinal rod cell	4 studies	28% ± 13%	Explore
innate lymphoid cell	4 studies	19% ± 3%	Explore
type I pneumocyte	4 studies	22% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
exhausted T cell	3 studies	23% ± 7%	Explore
GABAergic interneuron	3 studies	26% ± 5%	Explore
progenitor cell	3 studies	31% ± 8%	Explore
plasma cell	3 studies	30% ± 4%	Explore
squamous epithelial cell	3 studies	35% ± 23%	Explore
mesothelial cell	3 studies	31% ± 14%	Explore
vein endothelial cell	3 studies	29% ± 16%	Explore
Mueller cell	3 studies	30% ± 15%	Explore
OFF-bipolar cell	3 studies	37% ± 16%	Explore
ON-bipolar cell	3 studies	38% ± 16%	Explore
rod bipolar cell	3 studies	22% ± 9%	Explore
respiratory goblet cell	3 studies	24% ± 1%	Explore
hepatocyte	3 studies	34% ± 9%	Explore
neural progenitor cell	3 studies	33% ± 9%	Explore
ependymal cell	3 studies	37% ± 14%	Explore
alveolar macrophage	3 studies	32% ± 10%	Explore
transit amplifying cell	3 studies	38% ± 28%	Explore
brush cell	3 studies	25% ± 10%	Explore
T-helper 17 cell	3 studies	21% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	20% ± 2%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
double negative thymocyte	3 studies	24% ± 5%	Explore
mural cell	3 studies	39% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	34% ± 18%	Explore
peripheral blood	12 studies	22% ± 6%	Explore
lung	8 studies	23% ± 6%	Explore
eye	5 studies	32% ± 14%	Explore
heart	4 studies	27% ± 5%	Explore
kidney	4 studies	20% ± 4%	Explore
adipose	4 studies	31% ± 6%	Explore
bone marrow	3 studies	22% ± 3%	Explore
liver	3 studies	27% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3877.68	1444 / 1445	100%	35.33	183 / 183
thymus	100%	5393.66	653 / 653	100%	34.01	604 / 605
bladder	100%	3859.10	21 / 21	100%	19.91	503 / 504
lung	100%	4166.07	578 / 578	100%	25.11	1152 / 1155
brain	100%	2676.74	2633 / 2642	100%	35.10	705 / 705
breast	100%	4834.31	459 / 459	100%	33.54	1113 / 1118
ovary	100%	4467.94	180 / 180	100%	25.04	428 / 430
intestine	100%	4068.87	966 / 966	99%	18.64	520 / 527
stomach	100%	2673.17	359 / 359	99%	21.86	282 / 286
uterus	100%	4918.35	170 / 170	98%	19.95	452 / 459
kidney	100%	2593.00	89 / 89	98%	23.83	887 / 901
prostate	100%	3657.30	245 / 245	98%	18.35	494 / 502
skin	100%	4911.34	1809 / 1809	98%	22.69	462 / 472
pancreas	99%	2069.39	325 / 328	98%	18.14	174 / 178
adrenal gland	99%	3979.47	255 / 258	98%	17.60	225 / 230
liver	99%	1928.11	223 / 226	76%	8.79	308 / 406
adipose	100%	4855.15	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3816.68	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.30	29 / 29
spleen	100%	5866.61	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	26.05	45 / 45
ureter	0%	0	0 / 0	100%	7.19	1 / 1
muscle	100%	3482.62	800 / 803	0%	0	0 / 0
peripheral blood	98%	3908.08	915 / 929	0%	0	0 / 0
heart	98%	2812.04	843 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	13.96	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031647	Biological process	regulation of protein stability
GO_0090309	Biological process	positive regulation of DNA methylation-dependent heterochromatin formation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0050821	Biological process	protein stabilization
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0003714	Molecular function	transcription corepressor activity
GO_0005515	Molecular function	protein binding
GO_0003712	Molecular function	transcription coregulator activity
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ATF7IP
Protein name	Activating transcription factor 7 interacting protein Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)
Synonyms	MCAF MCAF1
Description	FUNCTION: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing . Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 . Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) . Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells . .
Accessions	Q6VMQ6 F8WE35 ENST00000535132.1 H0YFA3 ENST00000261168.9 [Q6VMQ6-1] ENST00000543189.5 [Q6VMQ6-2] ENST00000535738.1 F5GZ10 A8MV73 F5H221 ENST00000428217.6 F5GYR7 F5H2H9 ENST00000534828.1 ENST00000545769.1 F5H1K9 ENST00000536279.1 F5H8I0 F5GZ98 ENST00000544627.5 [Q6VMQ6-4] ENST00000542508.1 ENST00000541056.1 F5H3C4 ENST00000542967.1 ENST00000538511.5 ENST00000545723.1 ENST00000540793.5 [Q6VMQ6-1] ENST00000542991.1 ENST00000536444.5 [Q6VMQ6-5] F5H502 F5H592 F5H2W9 ENST00000542514.5 F5H6X8 ENST00000539057.1 ENST00000396279.2

ATF7IP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review