PIAS4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_1902231Biological processpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0043488Biological processregulation of mRNA stability
GO_0006302Biological processdouble-strand break repair
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060887Biological processlimb epidermis development
GO_1902174Biological processpositive regulation of keratinocyte apoptotic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0120186Biological processnegative regulation of protein localization to chromatin
GO_0042359Biological processvitamin D metabolic process
GO_0033235Biological processpositive regulation of protein sumoylation
GO_0001942Biological processhair follicle development
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0007417Biological processcentral nervous system development
GO_0016055Biological processWnt signaling pathway
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0016605Cellular componentPML body
GO_1990234Cellular componenttransferase complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019789Molecular functionSUMO transferase activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0061665Molecular functionSUMO ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIAS4
Protein nameE3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)
PIAS4 protein
SynonymsPIASG
DescriptionFUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor . Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168 . Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway . Involved in gene silencing . In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations . Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation . Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs) (By similarity). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) . Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin . .

AccessionsENST00000262971.3
Q8N2W9
Q05DS6