ATN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001906Biological processcell killing
GO_0030011Biological processmaintenance of cell polarity
GO_0007283Biological processspermatogenesis
GO_0009791Biological processpost-embryonic development
GO_0008340Biological processdetermination of adult lifespan
GO_0035264Biological processmulticellular organism growth
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0051402Biological processneuron apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007417Biological processcentral nervous system development
GO_0008584Biological processmale gonad development
GO_0032094Biological processresponse to food
GO_0016477Biological processcell migration
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0070161Cellular componentanchoring junction
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019904Molecular functionprotein domain specific binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATN1
Protein nameAtrophin 1
Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)
SynonymsD12S755E
DRPLA
DescriptionFUNCTION: Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. .

AccessionsQ86V38
ENST00000396684.3
P54259
ENST00000356654.8