HNRNPU report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000373Biological processpositive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO_0051301Biological processcell division
GO_0048255Biological processmRNA stabilization
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_0007346Biological processregulation of mitotic cell cycle
GO_0070934Biological processCRD-mediated mRNA stabilization
GO_0009048Biological processdosage compensation by inactivation of X chromosome
GO_0001649Biological processosteoblast differentiation
GO_1990280Biological processRNA localization to chromatin
GO_0000398Biological processmRNA splicing, via spliceosome
GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_1902275Biological processregulation of chromatin organization
GO_0055013Biological processcardiac muscle cell development
GO_0006396Biological processRNA processing
GO_1902889Biological processprotein localization to spindle microtubule
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_1990845Biological processadaptive thermogenesis
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0033673Biological processnegative regulation of kinase activity
GO_1902425Biological processpositive regulation of attachment of mitotic spindle microtubules to kinetochore
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006325Biological processchromatin organization
GO_1901673Biological processregulation of mitotic spindle assembly
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032922Biological processcircadian regulation of gene expression
GO_0051457Biological processmaintenance of protein location in nucleus
GO_0090336Biological processpositive regulation of brown fat cell differentiation
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_1900152Biological processnegative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0098963Biological processdendritic transport of messenger ribonucleoprotein complex
GO_1990498Cellular componentmitotic spindle microtubule
GO_0009986Cellular componentcell surface
GO_0098577Cellular componentinactive sex chromosome
GO_0070937Cellular componentCRD-mediated mRNA stability complex
GO_0032839Cellular componentdendrite cytoplasm
GO_0005634Cellular componentnucleus
GO_0000922Cellular componentspindle pole
GO_0072686Cellular componentmitotic spindle
GO_0000228Cellular componentnuclear chromosome
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0030496Cellular componentmidbody
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_1990023Cellular componentmitotic spindle midzone
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0016607Cellular componentnuclear speck
GO_0000776Cellular componentkinetochore
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0017130Molecular functionpoly(C) RNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0031490Molecular functionchromatin DNA binding
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0001097Molecular functionTFIIH-class transcription factor complex binding
GO_0017069Molecular functionsnRNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003682Molecular functionchromatin binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0003779Molecular functionactin binding
GO_0034046Molecular functionpoly(G) binding
GO_0106222Molecular functionlncRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0008143Molecular functionpoly(A) binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0044877Molecular functionprotein-containing complex binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0070034Molecular functiontelomerase RNA binding
GO_0099122Molecular functionRNA polymerase II C-terminal domain binding
GO_0036002Molecular functionpre-mRNA binding

IV. Literature review

[source]
Gene nameHNRNPU
Protein nameHeterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120)
Heterogeneous nuclear ribonucleoprotein U
SynonymsU21.1
SAFA
C1orf199
HNRPU
DescriptionFUNCTION: DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression . Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability . Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator . Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner . Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation . Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus . Negatively regulates glucocorticoid-mediated transcriptional activation . Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression . Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length . Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis . Plays a role in mRNA stability . Component of the CRD-mediated complex that promotes MYC mRNA stabilization . Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) . Plays a role in mitotic cell cycle regulation . Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression . Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis . Contributes also to the targeting of AURKA to mitotic spindle MTs . Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides . Binds to chromatin-associated RNAs (caRNAs) . Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner . Binds to the Xist RNA . Binds the long non-coding H19 RNA . Binds to SMN1/2 pre-mRNAs at G/U-rich regions . Binds to small nuclear RNAs (snRNAs) . Binds to the 3'-UTR of TNFA mRNA . Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). .; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. .

AccessionsENST00000704074.1
ENST00000638716.1
ENST00000444376.7 [Q00839-2]
A0A1W2PPH7
ENST00000639880.1
A0A1W2PQ74
ENST00000640306.1
Q00839
A0A1W2PP35
ENST00000489705.2
ENST00000638230.1
A0A1W2PP34
ENST00000640001.1
ENST00000283179.14
ENST00000639628.2
A0A1W2PQL0
ENST00000639824.1
A0A1W2PPE9
A0A087WZF3
A0A1X7SBS1
Q5RI18
A0A087WVI9
ENST00000640056.1
ENST00000483966.3
A0A1W2PQD4
ENST00000640119.1
ENST00000638301.1
A0A1W2PRZ7
ENST00000440865.2
ENST00000638475.1
A0A1W2PRI6
ENST00000475997.6
ENST00000640440.1
A0A1W2PPL4
A0A1W2PNG3
A0A994J6V2
ENST00000640218.2 [Q00839-1]
A0A1W2PPS1
A0A1W2PP22