GMNN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045786Biological processnegative regulation of cell cycle
GO_0009887Biological processanimal organ morphogenesis
GO_0008156Biological processnegative regulation of DNA replication
GO_0007346Biological processregulation of mitotic cell cycle
GO_0030174Biological processregulation of DNA-templated DNA replication initiation
GO_0035563Biological processpositive regulation of chromatin binding
GO_2000104Biological processnegative regulation of DNA-templated DNA replication
GO_0071163Biological processDNA replication preinitiation complex assembly
GO_0006275Biological processregulation of DNA replication
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameGMNN
Protein nameGeminin
Geminin DNA replication inhibitor
Synonyms
DescriptionFUNCTION: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) . It is degraded during the mitotic phase of the cell cycle . Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle . Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing . Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control . .

AccessionsENST00000378059.3
H7C608
ENST00000356509.7
O75496
E2QRF9
ENST00000378054.6
ENST00000476555.5
C9K0U5
ENST00000230056.8
ENST00000620958.4