Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 8 studies | 38% ± 14% | |
| plasmablast | 5 studies | 29% ± 15% | |
| CD8-positive, alpha-beta T cell | 5 studies | 19% ± 2% | |
| natural killer cell | 5 studies | 21% ± 5% | |
| hematopoietic precursor cell | 4 studies | 21% ± 9% | |
| megakaryocyte-erythroid progenitor cell | 4 studies | 24% ± 7% | |
| transit amplifying cell | 4 studies | 28% ± 7% | |
| CD4-positive, alpha-beta T cell | 4 studies | 18% ± 2% | |
| ciliated cell | 3 studies | 29% ± 16% | |
| erythroblast | 3 studies | 50% ± 16% | |
| erythrocyte | 3 studies | 30% ± 18% | |
| pancreatic ductal cell | 3 studies | 41% ± 14% | |
| abnormal cell | 3 studies | 19% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 33% ± 23% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 689.71 | 21 / 21 | 100% | 50.55 | 503 / 504 |
| ovary | 100% | 732.33 | 180 / 180 | 98% | 28.41 | 423 / 430 |
| brain | 98% | 804.25 | 2595 / 2642 | 100% | 41.25 | 702 / 705 |
| uterus | 98% | 465.20 | 167 / 170 | 99% | 58.53 | 456 / 459 |
| pancreas | 100% | 2288.56 | 328 / 328 | 97% | 23.15 | 173 / 178 |
| prostate | 99% | 1723.96 | 242 / 245 | 98% | 47.07 | 491 / 502 |
| intestine | 98% | 876.58 | 944 / 966 | 99% | 37.98 | 521 / 527 |
| liver | 98% | 484.59 | 222 / 226 | 98% | 60.63 | 399 / 406 |
| breast | 99% | 689.57 | 456 / 459 | 97% | 26.06 | 1086 / 1118 |
| lung | 98% | 482.11 | 567 / 578 | 98% | 32.75 | 1132 / 1155 |
| stomach | 97% | 827.65 | 350 / 359 | 99% | 31.56 | 282 / 286 |
| skin | 100% | 1498.04 | 1806 / 1809 | 95% | 29.51 | 447 / 472 |
| esophagus | 94% | 464.50 | 1355 / 1445 | 99% | 30.04 | 181 / 183 |
| thymus | 100% | 607.61 | 650 / 653 | 93% | 18.52 | 563 / 605 |
| kidney | 100% | 690.21 | 89 / 89 | 82% | 12.20 | 740 / 901 |
| adrenal gland | 95% | 371.49 | 244 / 258 | 87% | 17.42 | 199 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 47.39 | 29 / 29 |
| spleen | 100% | 971.63 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 38.99 | 1 / 1 |
| adipose | 98% | 475.11 | 1181 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 54.46 | 44 / 45 |
| blood vessel | 93% | 354.22 | 1246 / 1335 | 0% | 0 | 0 / 0 |
| heart | 72% | 202.47 | 618 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 59% | 7.27 | 47 / 80 |
| muscle | 53% | 138.88 | 422 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 37% | 557.35 | 341 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045786 | Biological process | negative regulation of cell cycle |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0008156 | Biological process | negative regulation of DNA replication |
| GO_0007346 | Biological process | regulation of mitotic cell cycle |
| GO_0030174 | Biological process | regulation of DNA-templated DNA replication initiation |
| GO_0035563 | Biological process | positive regulation of chromatin binding |
| GO_2000104 | Biological process | negative regulation of DNA-templated DNA replication |
| GO_0071163 | Biological process | DNA replication preinitiation complex assembly |
| GO_0006275 | Biological process | regulation of DNA replication |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0017053 | Cellular component | transcription repressor complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0042826 | Molecular function | histone deacetylase binding |
| Gene name | GMNN |
| Protein name | Geminin Geminin DNA replication inhibitor |
| Synonyms | |
| Description | FUNCTION: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) . It is degraded during the mitotic phase of the cell cycle . Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle . Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing . Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control . . |
| Accessions | ENST00000378059.3 H7C608 ENST00000356509.7 O75496 E2QRF9 ENST00000378054.6 ENST00000476555.5 C9K0U5 ENST00000230056.8 ENST00000620958.4 |