SNW1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0048385Biological processregulation of retinoic acid receptor signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070564Biological processpositive regulation of vitamin D receptor signaling pathway
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0050769Biological processpositive regulation of neurogenesis
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0043923Biological processpositive regulation by host of viral transcription
GO_0048384Biological processretinoic acid receptor signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0070562Biological processregulation of vitamin D receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0008024Cellular componentcyclin/CDK positive transcription elongation factor complex
GO_0005681Cellular componentspliceosomal complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0071007Cellular componentU2-type catalytic step 2 spliceosome
GO_0016363Cellular componentnuclear matrix
GO_0016604Cellular componentnuclear body
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0016922Molecular functionnuclear receptor binding
GO_0005112Molecular functionNotch binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0046332Molecular functionSMAD binding
GO_0042974Molecular functionnuclear retinoic acid receptor binding
GO_0003723Molecular functionRNA binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0042809Molecular functionnuclear vitamin D receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNW1
Protein nameSNW domain containing 1
SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)
SNW domain-containing protein 1
SynonymsSKIP
SKIIP
DescriptionFUNCTION: Involved in pre-mRNA splicing as component of the spliceosome . As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. .; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. .; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. .

FUNCTION: Involved in pre-mRNA splicing. .

FUNCTION: Involved in pre-mRNA splicing. .

FUNCTION: Involved in pre-mRNA splicing. .

FUNCTION: Involved in pre-mRNA splicing. .

FUNCTION: Involved in pre-mRNA splicing. .

FUNCTION: Involved in pre-mRNA splicing. .

AccessionsG3V3A4
Q6I9S2
ENST00000556428.5
ENST00000261531.12
ENST00000554324.1
Q6P151
G3V5R3
Q0D2M5
ENST00000555761.5
G3V4X8
ENST00000554775.5
G3V4E0
Q13573