TCF25 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	37% ± 12%	Explore
fibroblast	43 studies	37% ± 12%	Explore
natural killer cell	40 studies	44% ± 15%	Explore
B cell	39 studies	36% ± 11%	Explore
macrophage	37 studies	35% ± 11%	Explore
pericyte	35 studies	38% ± 11%	Explore
CD8-positive, alpha-beta T cell	35 studies	34% ± 13%	Explore
CD4-positive, alpha-beta T cell	32 studies	33% ± 11%	Explore
T cell	31 studies	34% ± 10%	Explore
smooth muscle cell	30 studies	35% ± 11%	Explore
conventional dendritic cell	27 studies	38% ± 15%	Explore
mast cell	25 studies	34% ± 13%	Explore
classical monocyte	25 studies	43% ± 14%	Explore
dendritic cell	24 studies	41% ± 19%	Explore
non-classical monocyte	23 studies	45% ± 14%	Explore
regulatory T cell	23 studies	36% ± 7%	Explore
monocyte	21 studies	37% ± 11%	Explore
plasmacytoid dendritic cell	21 studies	48% ± 14%	Explore
plasma cell	20 studies	41% ± 16%	Explore
mature NK T cell	20 studies	41% ± 11%	Explore
memory B cell	20 studies	36% ± 8%	Explore
basal cell	20 studies	35% ± 18%	Explore
epithelial cell	20 studies	38% ± 21%	Explore
endothelial cell of lymphatic vessel	19 studies	30% ± 8%	Explore
ciliated cell	19 studies	43% ± 17%	Explore
naive B cell	19 studies	36% ± 10%	Explore
connective tissue cell	18 studies	36% ± 12%	Explore
astrocyte	17 studies	34% ± 15%	Explore
gamma-delta T cell	17 studies	42% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	45% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	54% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	35% ± 11%	Explore
myofibroblast cell	15 studies	41% ± 10%	Explore
mucosal invariant T cell	15 studies	40% ± 10%	Explore
myeloid cell	15 studies	38% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	39% ± 11%	Explore
capillary endothelial cell	13 studies	32% ± 6%	Explore
vein endothelial cell	13 studies	32% ± 10%	Explore
endothelial cell of vascular tree	13 studies	29% ± 11%	Explore
type I pneumocyte	12 studies	35% ± 11%	Explore
plasmablast	12 studies	46% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	40% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	42% ± 11%	Explore
microglial cell	12 studies	35% ± 12%	Explore
oligodendrocyte precursor cell	12 studies	31% ± 14%	Explore
type II pneumocyte	11 studies	31% ± 11%	Explore
club cell	11 studies	33% ± 9%	Explore
secretory cell	11 studies	37% ± 17%	Explore
glutamatergic neuron	11 studies	41% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	44% ± 13%	Explore
endothelial cell of artery	11 studies	30% ± 7%	Explore
leukocyte	10 studies	34% ± 9%	Explore
abnormal cell	10 studies	33% ± 13%	Explore
neuron	10 studies	43% ± 17%	Explore
mesothelial cell	10 studies	36% ± 11%	Explore
adipocyte	10 studies	34% ± 9%	Explore
oligodendrocyte	9 studies	32% ± 13%	Explore
goblet cell	9 studies	38% ± 18%	Explore
GABAergic neuron	9 studies	41% ± 21%	Explore
alveolar macrophage	8 studies	31% ± 11%	Explore
innate lymphoid cell	8 studies	34% ± 12%	Explore
respiratory goblet cell	8 studies	41% ± 12%	Explore
progenitor cell	8 studies	28% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	40% ± 9%	Explore
kidney loop of Henle epithelial cell	7 studies	23% ± 7%	Explore
amacrine cell	7 studies	59% ± 13%	Explore
retinal cone cell	7 studies	35% ± 11%	Explore
retinal rod cell	7 studies	26% ± 6%	Explore
hematopoietic stem cell	7 studies	39% ± 10%	Explore
T follicular helper cell	7 studies	33% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	36% ± 9%	Explore
hematopoietic precursor cell	6 studies	39% ± 17%	Explore
ionocyte	6 studies	35% ± 12%	Explore
neutrophil	6 studies	21% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	35% ± 7%	Explore
mononuclear phagocyte	6 studies	39% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	6 studies	26% ± 8%	Explore
renal alpha-intercalated cell	6 studies	31% ± 7%	Explore
IgA plasma cell	6 studies	31% ± 13%	Explore
IgG plasma cell	6 studies	30% ± 10%	Explore
transit amplifying cell	6 studies	29% ± 24%	Explore
retina horizontal cell	6 studies	59% ± 14%	Explore
interneuron	6 studies	41% ± 25%	Explore
retinal ganglion cell	6 studies	77% ± 20%	Explore
lymphocyte	6 studies	43% ± 13%	Explore
precursor B cell	6 studies	32% ± 7%	Explore
mucus secreting cell	6 studies	31% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	44% ± 13%	Explore
exhausted T cell	5 studies	45% ± 12%	Explore
platelet	5 studies	21% ± 7%	Explore
glial cell	5 studies	32% ± 17%	Explore
pro-B cell	5 studies	26% ± 3%	Explore
brush cell	5 studies	33% ± 8%	Explore
adventitial cell	5 studies	28% ± 7%	Explore
cardiac muscle cell	5 studies	22% ± 3%	Explore
Mueller cell	5 studies	35% ± 6%	Explore
hepatocyte	5 studies	41% ± 21%	Explore
CD4-positive helper T cell	4 studies	33% ± 13%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	31% ± 9%	Explore
deuterosomal cell	4 studies	47% ± 10%	Explore
duct epithelial cell	4 studies	38% ± 14%	Explore
squamous epithelial cell	4 studies	40% ± 22%	Explore
pancreatic A cell	4 studies	46% ± 4%	Explore
type B pancreatic cell	4 studies	35% ± 9%	Explore
epithelial cell of proximal tubule	4 studies	25% ± 4%	Explore
retinal bipolar neuron	4 studies	47% ± 10%	Explore
erythroblast	4 studies	32% ± 13%	Explore
enterocyte	4 studies	23% ± 2%	Explore
immature B cell	4 studies	37% ± 6%	Explore
retinal pigment epithelial cell	4 studies	44% ± 22%	Explore
intermediate monocyte	4 studies	62% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 5%	Explore
myoepithelial cell	4 studies	35% ± 8%	Explore
granulocyte	4 studies	29% ± 6%	Explore
enteroendocrine cell	4 studies	36% ± 12%	Explore
erythrocyte	4 studies	34% ± 12%	Explore
T-helper 17 cell	4 studies	31% ± 9%	Explore
double negative thymocyte	4 studies	51% ± 13%	Explore
renal principal cell	4 studies	26% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	32% ± 7%	Explore
glomerular endothelial cell	3 studies	40% ± 12%	Explore
podocyte	3 studies	38% ± 16%	Explore
neural crest cell	3 studies	31% ± 2%	Explore
GABAergic interneuron	3 studies	28% ± 6%	Explore
extravillous trophoblast	3 studies	50% ± 12%	Explore
placental villous trophoblast	3 studies	65% ± 13%	Explore
serous secreting cell	3 studies	24% ± 5%	Explore
tissue-resident macrophage	3 studies	35% ± 6%	Explore
OFF-bipolar cell	3 studies	54% ± 31%	Explore
ON-bipolar cell	3 studies	55% ± 30%	Explore
rod bipolar cell	3 studies	36% ± 9%	Explore
germinal center B cell	3 studies	30% ± 3%	Explore
muscle cell	3 studies	49% ± 10%	Explore
pancreatic ductal cell	3 studies	37% ± 7%	Explore
ependymal cell	3 studies	38% ± 15%	Explore
chondrocyte	3 studies	36% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	49% ± 14%	Explore
melanocyte	3 studies	45% ± 13%	Explore
keratinocyte	3 studies	23% ± 5%	Explore
granule cell	3 studies	30% ± 7%	Explore
T-helper 1 cell	3 studies	40% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	39% ± 4%	Explore
double-positive, alpha-beta thymocyte	3 studies	51% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	30% ± 2%	Explore
luminal cell of prostate epithelium	3 studies	28% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	38% ± 13%	Explore
peripheral blood	18 studies	44% ± 13%	Explore
brain	18 studies	34% ± 16%	Explore
intestine	11 studies	29% ± 12%	Explore
kidney	10 studies	29% ± 8%	Explore
eye	10 studies	38% ± 14%	Explore
liver	6 studies	37% ± 12%	Explore
lymph node	5 studies	32% ± 8%	Explore
breast	5 studies	30% ± 5%	Explore
pancreas	4 studies	38% ± 10%	Explore
placenta	4 studies	46% ± 11%	Explore
bone marrow	4 studies	33% ± 11%	Explore
heart	4 studies	29% ± 3%	Explore
uterus	4 studies	45% ± 17%	Explore
adipose	4 studies	40% ± 10%	Explore
skin	3 studies	23% ± 2%	Explore
prostate	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7221.90	1445 / 1445	100%	28.78	183 / 183
pancreas	100%	4902.45	328 / 328	100%	40.92	178 / 178
skin	100%	7314.49	1809 / 1809	100%	50.94	472 / 472
stomach	100%	6760.69	359 / 359	100%	33.99	286 / 286
brain	100%	7260.34	2638 / 2642	100%	56.09	705 / 705
thymus	100%	9930.79	653 / 653	100%	53.64	604 / 605
lung	100%	7788.56	578 / 578	100%	35.45	1153 / 1155
prostate	100%	8575.50	245 / 245	100%	46.76	501 / 502
ovary	100%	8722.81	180 / 180	100%	28.65	429 / 430
breast	100%	7964.67	459 / 459	100%	36.09	1114 / 1118
intestine	100%	8028.98	966 / 966	100%	38.56	525 / 527
kidney	100%	6333.96	89 / 89	99%	35.23	896 / 901
bladder	100%	7731.38	21 / 21	99%	36.84	501 / 504
uterus	100%	8069.74	170 / 170	99%	37.62	456 / 459
liver	100%	4203.28	226 / 226	99%	22.84	402 / 406
adrenal gland	100%	9212.24	258 / 258	98%	45.28	226 / 230
adipose	100%	7456.96	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8042.72	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	71.24	80 / 80
lymph node	0%	0	0 / 0	100%	43.46	29 / 29
muscle	100%	4718.96	803 / 803	0%	0	0 / 0
spleen	100%	8988.62	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	33.57	45 / 45
ureter	0%	0	0 / 0	100%	30.27	1 / 1
heart	99%	4751.17	853 / 861	0%	0	0 / 0
peripheral blood	99%	6464.46	917 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	TCF25
Protein name	NULP1, isoform CRA_c (Transcription factor 25) (cDNA: FLJ21026 fis, clone CAE06812) Transcription factor 25 Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) PRO2620 (Transcription factor 25)
Synonyms	NULP1 KIAA1049 FKSG26 hCG_16354
Description	FUNCTION: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation . In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 . Also acts as a transcriptional repressor: represses transcription of SRF in vitro and so may play a role in heart development . May play a role in cell death control (By similarity). .
Accessions	Q9H384 ENST00000640279.1 H3BR53 H3BTU3 ENST00000614813.4 H3BRP4 ENST00000564652.5 ENST00000562193.1 H3BSP8 ENST00000568409.5 H3BS87 ENST00000562256.5 H3BQ53 ENST00000566283.1 ENST00000565404.1 H3BMJ8 Q9BQ70 H3BPU1 ENST00000568412.5 ENST00000263346.13 ENST00000565196.5 ENST00000561958.5 ENST00000263347.11 H3BSS3 Q9H7D3

GO_0061945	Biological process	regulation of protein K48-linked ubiquitination
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0072344	Biological process	rescue of stalled ribosome
GO_0007507	Biological process	heart development
GO_1990112	Cellular component	RQC complex
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0005515	Molecular function	protein binding

TCF25 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review