I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 24% ± 2% | |
| GABAergic neuron | 3 studies | 26% ± 6% | |
| glutamatergic neuron | 3 studies | 33% ± 7% | |
| astrocyte | 3 studies | 18% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 24% ± 2% | |
| GABAergic neuron | 3 studies | 26% ± 6% | |
| glutamatergic neuron | 3 studies | 33% ± 7% | |
| astrocyte | 3 studies | 18% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 23% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3985.34 | 1445 / 1445 | 100% | 12.31 | 183 / 183 |
| breast | 100% | 3204.06 | 459 / 459 | 100% | 19.01 | 1117 / 1118 |
| prostate | 100% | 3637.42 | 245 / 245 | 100% | 13.95 | 501 / 502 |
| stomach | 100% | 3238.99 | 359 / 359 | 100% | 11.54 | 285 / 286 |
| bladder | 100% | 4197.76 | 21 / 21 | 100% | 12.26 | 502 / 504 |
| uterus | 100% | 4008.22 | 170 / 170 | 100% | 14.74 | 457 / 459 |
| thymus | 100% | 3183.00 | 653 / 653 | 100% | 13.03 | 602 / 605 |
| lung | 100% | 3127.88 | 576 / 578 | 100% | 13.94 | 1153 / 1155 |
| kidney | 100% | 3342.00 | 89 / 89 | 99% | 13.62 | 896 / 901 |
| brain | 100% | 2775.38 | 2629 / 2642 | 100% | 12.96 | 703 / 705 |
| intestine | 100% | 4462.32 | 966 / 966 | 99% | 12.16 | 521 / 527 |
| pancreas | 100% | 2353.82 | 327 / 328 | 99% | 11.26 | 176 / 178 |
| skin | 100% | 4793.34 | 1809 / 1809 | 99% | 15.24 | 465 / 472 |
| ovary | 100% | 4162.58 | 180 / 180 | 97% | 9.47 | 415 / 430 |
| adrenal gland | 100% | 4001.61 | 258 / 258 | 96% | 14.90 | 221 / 230 |
| liver | 100% | 1587.66 | 226 / 226 | 87% | 6.48 | 354 / 406 |
| adipose | 100% | 2931.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3836.18 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 16.24 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 15.35 | 29 / 29 |
| muscle | 100% | 9985.31 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4246.22 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 16.76 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.24 | 1 / 1 |
| heart | 98% | 3093.56 | 842 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 93% | 3428.68 | 865 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045663 | Biological process | positive regulation of myoblast differentiation |
| GO_2001214 | Biological process | positive regulation of vasculogenesis |
| GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0036140 | Molecular function | [protein]-asparagine 3-dioxygenase activity |
| GO_0062101 | Molecular function | peptidyl-aspartic acid 3-dioxygenase activity |
| GO_0005112 | Molecular function | Notch binding |
| GO_0019826 | Molecular function | oxygen sensor activity |
| GO_0008198 | Molecular function | ferrous iron binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0036139 | Molecular function | peptidyl-histidine dioxygenase activity |
| GO_0031406 | Molecular function | carboxylic acid binding |
| GO_0071532 | Molecular function | ankyrin repeat binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0051059 | Molecular function | NF-kappaB binding |
| Gene name | HIF1AN |
| Protein name | Hypoxia inducible factor 1 subunit alpha inhibitor Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase) |
| Synonyms | FIH1 |
| Description | FUNCTION: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. . |
| Accessions | ENST00000299163.7 E9PL41 ENST00000526476.5 E9PNR8 Q9NWT6 ENST00000533589.6 |
