I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 22% ± 6% | |
| GABAergic neuron | 3 studies | 20% ± 6% | |
| glutamatergic neuron | 3 studies | 28% ± 7% | |
| basal cell | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 22% ± 6% | |
| GABAergic neuron | 3 studies | 20% ± 6% | |
| glutamatergic neuron | 3 studies | 28% ± 7% | |
| basal cell | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 950.46 | 180 / 180 | 100% | 10.17 | 430 / 430 |
| esophagus | 100% | 1142.37 | 1444 / 1445 | 100% | 13.05 | 183 / 183 |
| intestine | 100% | 980.66 | 965 / 966 | 100% | 11.70 | 525 / 527 |
| bladder | 100% | 1439.14 | 21 / 21 | 99% | 11.88 | 501 / 504 |
| prostate | 100% | 944.30 | 245 / 245 | 99% | 13.15 | 499 / 502 |
| lung | 99% | 921.85 | 575 / 578 | 100% | 11.97 | 1154 / 1155 |
| stomach | 100% | 867.13 | 359 / 359 | 99% | 11.50 | 284 / 286 |
| pancreas | 100% | 980.24 | 328 / 328 | 99% | 8.17 | 176 / 178 |
| thymus | 100% | 3117.96 | 653 / 653 | 99% | 18.92 | 598 / 605 |
| uterus | 100% | 983.61 | 170 / 170 | 99% | 11.45 | 453 / 459 |
| breast | 100% | 1318.00 | 459 / 459 | 98% | 11.85 | 1100 / 1118 |
| skin | 100% | 1581.64 | 1808 / 1809 | 98% | 12.06 | 464 / 472 |
| brain | 99% | 807.85 | 2626 / 2642 | 95% | 8.83 | 667 / 705 |
| liver | 99% | 682.65 | 224 / 226 | 93% | 7.09 | 377 / 406 |
| adrenal gland | 100% | 845.64 | 257 / 258 | 89% | 5.54 | 204 / 230 |
| kidney | 100% | 1066.96 | 89 / 89 | 83% | 4.74 | 749 / 901 |
| adipose | 100% | 1232.75 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 11.51 | 29 / 29 |
| muscle | 100% | 1815.48 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 717.67 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.21 | 1 / 1 |
| blood vessel | 100% | 856.25 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 13.14 | 43 / 45 |
| heart | 92% | 523.02 | 796 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 79% | 4.15 | 63 / 80 |
| peripheral blood | 47% | 514.63 | 432 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0042254 | Biological process | ribosome biogenesis |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0032452 | Molecular function | histone demethylase activity |
| GO_0036139 | Molecular function | peptidyl-histidine dioxygenase activity |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0032453 | Molecular function | histone H3K4 demethylase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0051864 | Molecular function | histone H3K36 demethylase activity |
| Gene name | RIOX2 |
| Protein name | Bifunctional lysine-specific demethylase and histidyl-hydroxylase (EC 1.14.11.-) Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX) Ribosomal oxygenase 2 |
| Synonyms | hCG_1811387 NO52 MINA53 MDIG MINA |
| Description | FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. . FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. . FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. . FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. . |
| Accessions | Q8IUF8 ENST00000394198.7 [Q8IUF8-1] ENST00000503097.1 ENST00000360258.8 [Q8IUF8-4] ENST00000514314.5 [Q8IUF8-2] A0A6M8YDW1 ENST00000506099.1 H0Y9L8 ENST00000507612.1 D6RCB6 H0Y8K4 ENST00000333396.11 [Q8IUF8-1] |
