SF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	43 studies	35% ± 13%	Explore
fibroblast	42 studies	32% ± 11%	Explore
B cell	41 studies	54% ± 18%	Explore
natural killer cell	38 studies	41% ± 15%	Explore
T cell	36 studies	41% ± 17%	Explore
CD8-positive, alpha-beta T cell	35 studies	44% ± 17%	Explore
macrophage	32 studies	29% ± 10%	Explore
CD4-positive, alpha-beta T cell	32 studies	50% ± 19%	Explore
pericyte	31 studies	33% ± 11%	Explore
smooth muscle cell	30 studies	31% ± 9%	Explore
conventional dendritic cell	28 studies	40% ± 18%	Explore
regulatory T cell	26 studies	53% ± 15%	Explore
classical monocyte	23 studies	36% ± 16%	Explore
endothelial cell of lymphatic vessel	21 studies	35% ± 11%	Explore
non-classical monocyte	21 studies	42% ± 19%	Explore
basal cell	21 studies	33% ± 17%	Explore
mast cell	20 studies	31% ± 13%	Explore
monocyte	20 studies	32% ± 11%	Explore
memory B cell	20 studies	63% ± 13%	Explore
naive B cell	20 studies	60% ± 13%	Explore
plasmacytoid dendritic cell	20 studies	53% ± 17%	Explore
mature NK T cell	19 studies	42% ± 16%	Explore
gamma-delta T cell	18 studies	49% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	57% ± 17%	Explore
ciliated cell	18 studies	39% ± 17%	Explore
epithelial cell	18 studies	38% ± 23%	Explore
dendritic cell	17 studies	45% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	50% ± 17%	Explore
mucosal invariant T cell	16 studies	51% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	51% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	58% ± 17%	Explore
capillary endothelial cell	14 studies	28% ± 10%	Explore
myofibroblast cell	14 studies	35% ± 11%	Explore
connective tissue cell	14 studies	33% ± 9%	Explore
myeloid cell	14 studies	33% ± 16%	Explore
astrocyte	14 studies	35% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	50% ± 20%	Explore
endothelial cell of vascular tree	13 studies	32% ± 9%	Explore
plasma cell	12 studies	32% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	57% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	55% ± 14%	Explore
vein endothelial cell	12 studies	32% ± 12%	Explore
microglial cell	12 studies	31% ± 12%	Explore
oligodendrocyte precursor cell	12 studies	34% ± 15%	Explore
oligodendrocyte	12 studies	40% ± 17%	Explore
secretory cell	11 studies	31% ± 12%	Explore
type I pneumocyte	10 studies	33% ± 16%	Explore
club cell	10 studies	29% ± 13%	Explore
abnormal cell	10 studies	40% ± 14%	Explore
endothelial cell of artery	10 studies	29% ± 6%	Explore
type II pneumocyte	9 studies	29% ± 13%	Explore
plasmablast	9 studies	50% ± 23%	Explore
leukocyte	9 studies	38% ± 12%	Explore
mesothelial cell	9 studies	36% ± 16%	Explore
adipocyte	9 studies	36% ± 17%	Explore
innate lymphoid cell	8 studies	43% ± 13%	Explore
goblet cell	8 studies	32% ± 18%	Explore
T follicular helper cell	8 studies	55% ± 15%	Explore
glutamatergic neuron	8 studies	38% ± 24%	Explore
hematopoietic stem cell	8 studies	52% ± 22%	Explore
neutrophil	7 studies	19% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	43% ± 10%	Explore
progenitor cell	7 studies	35% ± 18%	Explore
neuron	7 studies	44% ± 20%	Explore
amacrine cell	7 studies	39% ± 16%	Explore
retinal rod cell	7 studies	35% ± 6%	Explore
precursor B cell	7 studies	66% ± 13%	Explore
immature B cell	7 studies	65% ± 10%	Explore
GABAergic neuron	7 studies	33% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	39% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	48% ± 13%	Explore
mononuclear phagocyte	6 studies	31% ± 15%	Explore
lymphocyte	6 studies	42% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	61% ± 18%	Explore
CD4-positive helper T cell	5 studies	50% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	53% ± 11%	Explore
hematopoietic precursor cell	5 studies	63% ± 22%	Explore
exhausted T cell	5 studies	49% ± 13%	Explore
respiratory goblet cell	5 studies	33% ± 13%	Explore
enteroendocrine cell	5 studies	35% ± 12%	Explore
transit amplifying cell	5 studies	38% ± 26%	Explore
glial cell	5 studies	32% ± 17%	Explore
pro-B cell	5 studies	65% ± 16%	Explore
brush cell	5 studies	34% ± 12%	Explore
T-helper 17 cell	5 studies	47% ± 9%	Explore
retina horizontal cell	5 studies	35% ± 11%	Explore
cardiac muscle cell	5 studies	25% ± 7%	Explore
Mueller cell	5 studies	29% ± 6%	Explore
double negative thymocyte	5 studies	66% ± 8%	Explore
hepatocyte	5 studies	38% ± 23%	Explore
interneuron	5 studies	35% ± 18%	Explore
deuterosomal cell	4 studies	25% ± 8%	Explore
platelet	4 studies	29% ± 4%	Explore
pancreatic A cell	4 studies	47% ± 15%	Explore
enterocyte	4 studies	19% ± 2%	Explore
intestinal crypt stem cell	4 studies	23% ± 5%	Explore
retinal bipolar neuron	4 studies	48% ± 12%	Explore
retinal cone cell	4 studies	41% ± 14%	Explore
retinal pigment epithelial cell	4 studies	39% ± 18%	Explore
intermediate monocyte	4 studies	50% ± 26%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	52% ± 6%	Explore
granulocyte	4 studies	30% ± 13%	Explore
erythrocyte	4 studies	51% ± 5%	Explore
keratinocyte	4 studies	22% ± 4%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	38% ± 10%	Explore
ionocyte	3 studies	31% ± 10%	Explore
precursor cell	3 studies	59% ± 19%	Explore
pancreatic D cell	3 studies	46% ± 21%	Explore
type B pancreatic cell	3 studies	52% ± 12%	Explore
glomerular endothelial cell	3 studies	30% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 2%	Explore
renal alpha-intercalated cell	3 studies	34% ± 7%	Explore
neural crest cell	3 studies	39% ± 8%	Explore
retinal ganglion cell	3 studies	42% ± 15%	Explore
kidney loop of Henle epithelial cell	3 studies	25% ± 1%	Explore
erythroblast	3 studies	60% ± 19%	Explore
tissue-resident macrophage	3 studies	34% ± 17%	Explore
rod bipolar cell	3 studies	39% ± 12%	Explore
germinal center B cell	3 studies	51% ± 9%	Explore
endothelial cell of sinusoid	3 studies	20% ± 3%	Explore
muscle cell	3 studies	45% ± 17%	Explore
pancreatic ductal cell	3 studies	50% ± 20%	Explore
neural progenitor cell	3 studies	32% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	65% ± 28%	Explore
alveolar macrophage	3 studies	32% ± 9%	Explore
chondrocyte	3 studies	33% ± 9%	Explore
mucus secreting cell	3 studies	23% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	68% ± 17%	Explore
melanocyte	3 studies	42% ± 14%	Explore
granule cell	3 studies	24% ± 10%	Explore
T-helper 1 cell	3 studies	53% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	64% ± 5%	Explore
double-positive, alpha-beta thymocyte	3 studies	77% ± 12%	Explore
myoepithelial cell	3 studies	42% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	39% ± 7%	Explore
mural cell	3 studies	29% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	26% ± 6%	Explore
IgA plasma cell	3 studies	20% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	54% ± 16%	Explore
brain	18 studies	32% ± 19%	Explore
lung	17 studies	35% ± 11%	Explore
intestine	10 studies	30% ± 13%	Explore
eye	9 studies	40% ± 12%	Explore
kidney	7 studies	29% ± 7%	Explore
liver	6 studies	37% ± 14%	Explore
lymph node	5 studies	48% ± 12%	Explore
breast	5 studies	35% ± 9%	Explore
placenta	4 studies	22% ± 6%	Explore
bone marrow	4 studies	41% ± 21%	Explore
heart	4 studies	26% ± 4%	Explore
uterus	4 studies	43% ± 13%	Explore
prostate	4 studies	25% ± 6%	Explore
adipose	4 studies	41% ± 17%	Explore
pancreas	3 studies	53% ± 11%	Explore
skin	3 studies	23% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	18625.48	21 / 21	100%	121.21	504 / 504
esophagus	100%	17647.16	1445 / 1445	100%	141.88	183 / 183
intestine	100%	19307.62	966 / 966	100%	125.54	527 / 527
liver	100%	9523.66	226 / 226	100%	69.01	406 / 406
ovary	100%	27042.04	180 / 180	100%	133.51	430 / 430
pancreas	100%	10587.18	328 / 328	100%	106.62	178 / 178
prostate	100%	21838.70	245 / 245	100%	151.47	502 / 502
skin	100%	16936.02	1809 / 1809	100%	147.99	472 / 472
stomach	100%	14852.14	359 / 359	100%	123.88	286 / 286
thymus	100%	21477.26	653 / 653	100%	140.73	605 / 605
uterus	100%	22629.77	170 / 170	100%	134.64	459 / 459
lung	100%	17280.69	578 / 578	100%	123.94	1153 / 1155
breast	100%	20780.66	459 / 459	99%	136.96	1110 / 1118
brain	99%	11925.04	2622 / 2642	100%	161.66	705 / 705
kidney	100%	15056.21	89 / 89	99%	96.62	894 / 901
adrenal gland	100%	14939.39	258 / 258	98%	93.63	226 / 230
adipose	100%	20001.30	1204 / 1204	0%	0	0 / 0
blood vessel	100%	18237.32	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	156.78	80 / 80
lymph node	0%	0	0 / 0	100%	151.06	29 / 29
muscle	100%	14367.15	803 / 803	0%	0	0 / 0
spleen	100%	25526.34	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	134.74	45 / 45
ureter	0%	0	0 / 0	100%	89.20	1 / 1
peripheral blood	99%	18433.38	922 / 929	0%	0	0 / 0
heart	99%	10755.67	854 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030238	Biological process	male sex determination
GO_0000389	Biological process	mRNA 3'-splice site recognition
GO_0050810	Biological process	regulation of steroid biosynthetic process
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0048024	Biological process	regulation of mRNA splicing, via spliceosome
GO_0048662	Biological process	negative regulation of smooth muscle cell proliferation
GO_0033327	Biological process	Leydig cell differentiation
GO_0000245	Biological process	spliceosomal complex assembly
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0030575	Biological process	nuclear body organization
GO_0005681	Cellular component	spliceosomal complex
GO_0005840	Cellular component	ribosome
GO_0089701	Cellular component	U2AF complex
GO_0005654	Cellular component	nucleoplasm
GO_0016604	Cellular component	nuclear body
GO_0005634	Cellular component	nucleus
GO_0003714	Molecular function	transcription corepressor activity
GO_0042802	Molecular function	identical protein binding
GO_0003729	Molecular function	mRNA binding
GO_0008270	Molecular function	zinc ion binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SF1
Protein name	Alternative protein SF1 Splicing factor 1, isoform CRA_b (ZFM1 protein, alternatively spliced product) Splicing factor 1 Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)
Synonyms	ZFM1 hCG_23378 ZNF162
Description	FUNCTION: Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. . FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns. . FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns. . FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns. . FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns. .
Accessions	F8WEG7 ENST00000448404.5 ENST00000706685.1 ENST00000681407.1 ENST00000706686.1 A0A7P0T9U7 ENST00000486867.2 A0A9L9PXR5 ENST00000334944.9 [Q15637-2] F8WEV5 ENST00000432725.1 C9J792 ENST00000413951.5 Q15637 ENST00000443908.5 ENST00000227503.13 [Q15637-4] ENST00000706684.1 H7BZT1 Q14820 A0A9L9PXE4 H7C561 H7C0N4 ENST00000377387.5 [Q15637-5] ENST00000377394.7 [Q15637-6] ENST00000413725.5 ENST00000433274.6 [Q15637-7] A0A9L9PXU0 ENST00000377390.8 [Q15637-1] L0R8E5

SF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review