Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 9 studies | 24% ± 7% | |
| oligodendrocyte | 9 studies | 28% ± 9% | |
| endothelial cell | 8 studies | 28% ± 9% | |
| retinal rod cell | 7 studies | 36% ± 11% | |
| astrocyte | 7 studies | 27% ± 10% | |
| glutamatergic neuron | 6 studies | 40% ± 23% | |
| GABAergic neuron | 5 studies | 36% ± 17% | |
| oligodendrocyte precursor cell | 5 studies | 25% ± 11% | |
| macrophage | 5 studies | 21% ± 4% | |
| interneuron | 5 studies | 30% ± 18% | |
| neuron | 4 studies | 26% ± 13% | |
| retinal bipolar neuron | 4 studies | 18% ± 3% | |
| retinal ganglion cell | 4 studies | 30% ± 14% | |
| retinal cone cell | 4 studies | 25% ± 6% | |
| B cell | 3 studies | 16% ± 0% | |
| microglial cell | 3 studies | 25% ± 4% | |
| epithelial cell | 3 studies | 26% ± 1% | |
| amacrine cell | 3 studies | 19% ± 2% | |
| ciliated cell | 3 studies | 20% ± 4% | |
| fibroblast | 3 studies | 23% ± 6% | |
| endothelial cell of lymphatic vessel | 3 studies | 20% ± 3% | |
| pericyte | 3 studies | 23% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 6475.91 | 245 / 245 | 100% | 19.82 | 502 / 502 |
| thymus | 100% | 7323.88 | 653 / 653 | 100% | 33.83 | 605 / 605 |
| brain | 100% | 7377.97 | 2637 / 2642 | 100% | 34.62 | 705 / 705 |
| kidney | 100% | 6014.93 | 89 / 89 | 100% | 25.60 | 897 / 901 |
| bladder | 100% | 6860.52 | 21 / 21 | 99% | 14.73 | 501 / 504 |
| uterus | 100% | 9809.47 | 170 / 170 | 99% | 16.11 | 456 / 459 |
| breast | 100% | 8516.74 | 459 / 459 | 99% | 20.03 | 1109 / 1118 |
| skin | 100% | 5308.17 | 1807 / 1809 | 99% | 19.34 | 467 / 472 |
| intestine | 100% | 6681.40 | 966 / 966 | 98% | 13.03 | 519 / 527 |
| esophagus | 100% | 6592.75 | 1445 / 1445 | 98% | 13.32 | 180 / 183 |
| lung | 100% | 6225.53 | 578 / 578 | 98% | 15.36 | 1135 / 1155 |
| stomach | 99% | 4005.43 | 357 / 359 | 98% | 13.37 | 279 / 286 |
| adrenal gland | 99% | 4057.50 | 256 / 258 | 97% | 18.59 | 223 / 230 |
| ovary | 100% | 10467.28 | 180 / 180 | 96% | 11.21 | 413 / 430 |
| pancreas | 96% | 2408.05 | 314 / 328 | 98% | 18.10 | 174 / 178 |
| liver | 78% | 1446.81 | 177 / 226 | 92% | 9.57 | 373 / 406 |
| adipose | 100% | 8421.95 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 7355.52 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 23.60 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 20.18 | 29 / 29 |
| spleen | 100% | 8936.71 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 14.72 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.38 | 1 / 1 |
| muscle | 100% | 5865.71 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 4348.70 | 853 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 5422.40 | 914 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0021766 | Biological process | hippocampus development |
| GO_0032259 | Biological process | methylation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0031507 | Biological process | heterochromatin formation |
| GO_0031509 | Biological process | subtelomeric heterochromatin formation |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0000792 | Cellular component | heterochromatin |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0035098 | Cellular component | ESC/E(Z) complex |
| GO_0000781 | Cellular component | chromosome, telomeric region |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0042393 | Molecular function | histone binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0046976 | Molecular function | histone H3K27 methyltransferase activity |
| GO_0140951 | Molecular function | histone H3K27 trimethyltransferase activity |
| GO_0140693 | Molecular function | molecular condensate scaffold activity |
| GO_0031491 | Molecular function | nucleosome binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EZH1 |
| Protein name | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) Enhancer of zeste 1 polycomb repressive complex 2 subunit [histone H3]-lysine(27) N-trimethyltransferase (EC 2.1.1.356) |
| Synonyms | KIAA0388 |
| Description | FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. . |
| Accessions | ENST00000590078.5 [Q92800-4] ENST00000586382.5 ENST00000586867.5 ENST00000588239.5 ENST00000586089.5 K7EM79 K7ESB9 ENST00000592743.5 [Q92800-1] ENST00000588897.5 ENST00000586935.5 K7ENP2 ENST00000592492.5 K7EJU6 ENST00000415827.6 Q92800 K7EPC0 A0A0A0MSY9 ENST00000428826.7 [Q92800-1] ENST00000593214.5 K7EIH5 ENST00000585893.5 [Q92800-3] K7EK26 K7EK66 |