EZH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021766Biological processhippocampus development
GO_0032259Biological processmethylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0031507Biological processheterochromatin formation
GO_0031509Biological processsubtelomeric heterochromatin formation
GO_0009653Biological processanatomical structure morphogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000792Cellular componentheterochromatin
GO_0005654Cellular componentnucleoplasm
GO_0035098Cellular componentESC/E(Z) complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0046976Molecular functionhistone H3K27 methyltransferase activity
GO_0140951Molecular functionhistone H3K27 trimethyltransferase activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0031491Molecular functionnucleosome binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEZH1
Protein nameHistone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Enhancer of zeste 1 polycomb repressive complex 2 subunit
[histone H3]-lysine(27) N-trimethyltransferase (EC 2.1.1.356)
SynonymsKIAA0388
DescriptionFUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. .

AccessionsENST00000590078.5 [Q92800-4]
ENST00000586382.5
ENST00000586867.5
ENST00000588239.5
ENST00000586089.5
K7EM79
K7ESB9
ENST00000592743.5 [Q92800-1]
ENST00000588897.5
ENST00000586935.5
K7ENP2
ENST00000592492.5
K7EJU6
ENST00000415827.6
Q92800
K7EPC0
A0A0A0MSY9
ENST00000428826.7 [Q92800-1]
ENST00000593214.5
K7EIH5
ENST00000585893.5 [Q92800-3]
K7EK26
K7EK66