HIPK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0007628Biological processadult walking behavior
GO_0050882Biological processvoluntary musculoskeletal movement
GO_0060059Biological processembryonic retina morphogenesis in camera-type eye
GO_0007224Biological processsmoothened signaling pathway
GO_2000059Biological processnegative regulation of ubiquitin-dependent protein catabolic process
GO_0008283Biological processcell population proliferation
GO_0048596Biological processembryonic camera-type eye morphogenesis
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045766Biological processpositive regulation of angiogenesis
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032092Biological processpositive regulation of protein binding
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0030878Biological processthyroid gland development
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030578Biological processPML body organization
GO_0001654Biological processeye development
GO_0030218Biological processerythrocyte differentiation
GO_0030182Biological processneuron differentiation
GO_0051402Biological processneuron apoptotic process
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0060395Biological processSMAD protein signal transduction
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0060425Biological processlung morphogenesis
GO_0003016Biological processrespiratory system process
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0009952Biological processanterior/posterior pattern specification
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0060235Biological processlens induction in camera-type eye
GO_0061072Biological processiris morphogenesis
GO_0010467Biological processgene expression
GO_0006468Biological processprotein phosphorylation
GO_0040029Biological processepigenetic regulation of gene expression
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0051726Biological processregulation of cell cycle
GO_0071456Biological processcellular response to hypoxia
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010842Biological processretina layer formation
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0016604Cellular componentnuclear body
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0046332Molecular functionSMAD binding
GO_0004672Molecular functionprotein kinase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005524Molecular functionATP binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0046790Molecular functionvirion binding

IV. Literature review

[source]
Gene nameHIPK2
Protein nameHomeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)
Homeodomain interacting protein kinase 2
Alternative protein HIPK2
Synonymstcag7.426
DescriptionFUNCTION: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation . Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. .

AccessionsH7BXX9
ENST00000428878.6 [Q9H2X6-3]
Q9H2X6
ENST00000406875.8 [Q9H2X6-1]
A4D1R9
ENST00000342645.7
L8ECJ8