SIN3B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030336Biological processnegative regulation of cell migration
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0000806Cellular componentY chromosome
GO_0070822Cellular componentSin3-type complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0000805Cellular componentX chromosome
GO_0001741Cellular componentXY body
GO_0030849Cellular componentautosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameSIN3B
Protein namePaired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
SIN3 transcription regulator family member B
SynonymsKIAA0700
DescriptionFUNCTION: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 . SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription . .

AccessionsENST00000596802.5 [O75182-3]
M0QYC5
ENST00000595541.1
M0R271
O75182
ENST00000248054.10 [O75182-2]
ENST00000379803.5 [O75182-1]
ENST00000596638.1