Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 23% ± 9% | |
glutamatergic neuron | 7 studies | 35% ± 22% | |
macrophage | 5 studies | 22% ± 4% | |
neuron | 4 studies | 23% ± 8% | |
epithelial cell | 4 studies | 25% ± 6% | |
GABAergic neuron | 4 studies | 37% ± 18% | |
astrocyte | 4 studies | 28% ± 7% | |
endothelial cell of lymphatic vessel | 4 studies | 23% ± 9% | |
oligodendrocyte | 4 studies | 18% ± 1% | |
microglial cell | 3 studies | 20% ± 1% | |
oligodendrocyte precursor cell | 3 studies | 24% ± 6% | |
interneuron | 3 studies | 36% ± 22% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 6 studies | 32% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6561.36 | 1445 / 1445 | 100% | 29.44 | 183 / 183 |
prostate | 100% | 10306.17 | 245 / 245 | 100% | 23.87 | 502 / 502 |
skin | 100% | 5945.86 | 1809 / 1809 | 100% | 26.15 | 472 / 472 |
breast | 100% | 9366.26 | 459 / 459 | 100% | 23.52 | 1116 / 1118 |
uterus | 100% | 13900.30 | 170 / 170 | 100% | 25.29 | 458 / 459 |
ovary | 100% | 11795.98 | 180 / 180 | 100% | 35.00 | 429 / 430 |
lung | 100% | 9480.82 | 578 / 578 | 100% | 20.56 | 1152 / 1155 |
thymus | 100% | 9843.39 | 653 / 653 | 100% | 22.80 | 603 / 605 |
stomach | 100% | 4731.75 | 359 / 359 | 100% | 17.87 | 285 / 286 |
intestine | 100% | 7149.09 | 966 / 966 | 99% | 16.25 | 524 / 527 |
bladder | 100% | 7240.14 | 21 / 21 | 99% | 21.37 | 501 / 504 |
kidney | 100% | 6332.99 | 89 / 89 | 99% | 20.51 | 894 / 901 |
pancreas | 100% | 3066.96 | 327 / 328 | 99% | 21.89 | 177 / 178 |
adrenal gland | 100% | 6593.95 | 258 / 258 | 99% | 25.40 | 227 / 230 |
brain | 99% | 6647.73 | 2606 / 2642 | 100% | 35.70 | 705 / 705 |
liver | 96% | 2276.46 | 218 / 226 | 91% | 9.26 | 369 / 406 |
adipose | 100% | 7913.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 20.19 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.58 | 29 / 29 |
spleen | 100% | 9643.50 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.43 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.05 | 1 / 1 |
blood vessel | 100% | 5643.06 | 1332 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 2875.09 | 792 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 3661.21 | 848 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 86% | 2674.61 | 801 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0000806 | Cellular component | Y chromosome |
GO_0070822 | Cellular component | Sin3-type complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0000805 | Cellular component | X chromosome |
GO_0001741 | Cellular component | XY body |
GO_0030849 | Cellular component | autosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0003682 | Molecular function | chromatin binding |
Gene name | SIN3B |
Protein name | Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) SIN3 transcription regulator family member B |
Synonyms | KIAA0700 |
Description | FUNCTION: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 . SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription . . |
Accessions | ENST00000596802.5 [O75182-3] M0QYC5 ENST00000595541.1 M0R271 O75182 ENST00000248054.10 [O75182-2] ENST00000379803.5 [O75182-1] ENST00000596638.1 |