ENO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010756Biological processpositive regulation of plasminogen activation
GO_0006096Biological processglycolytic process
GO_0045933Biological processpositive regulation of muscle contraction
GO_0009615Biological processresponse to virus
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0061621Biological processcanonical glycolysis
GO_0006094Biological processgluconeogenesis
GO_1903298Biological processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_2001171Biological processpositive regulation of ATP biosynthetic process
GO_0030308Biological processnegative regulation of cell growth
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0000015Cellular componentphosphopyruvate hydratase complex
GO_0005640Cellular componentnuclear outer membrane
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0031430Cellular componentM band
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0045296Molecular functioncadherin binding
GO_0051020Molecular functionGTPase binding
GO_0004634Molecular functionphosphopyruvate hydratase activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0000287Molecular functionmagnesium ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameENO1
Protein namephosphopyruvate hydratase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase)
Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)
Enolase 1
SynonymsMBPB1
ENO1L1
MPB1
DescriptionFUNCTION: Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate . In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses . May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons . Stimulates immunoglobulin production . .; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. .

AccessionsP06733
K7EM90
A0A2R8Y798
ENST00000643438.1
A0A2R8YEG5
ENST00000646370.2
A0A2R8YEM5
ENST00000497492.1
A0A2R8Y879
ENST00000646660.1
ENST00000646156.1
K7ERS8
ENST00000647408.1
A0A2R8Y6I8
ENST00000489867.2
A4QMW8
ENST00000234590.10 [P06733-1]
ENST00000646680.1
ENST00000646906.1
A0A2R8Y6G6