NCOA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009966Biological processregulation of signal transduction
GO_0008286Biological processinsulin receptor signaling pathway
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0042593Biological processglucose homeostasis
GO_0005615Cellular componentextracellular space
GO_0015629Cellular componentactin cytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNCOA5
Protein nameNuclear receptor coactivator 5
Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)
SynonymsKIAA1637
DescriptionFUNCTION: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). .

AccessionsENST00000372291.3
ENST00000290231.11
Q9HCD5
Q5JY17