Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 5 studies | 25% ± 10% | |
oligodendrocyte precursor cell | 4 studies | 23% ± 7% | |
epithelial cell | 4 studies | 23% ± 3% | |
astrocyte | 4 studies | 26% ± 7% | |
microglial cell | 3 studies | 23% ± 2% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 20% ± 5% | |
gamma-delta T cell | 3 studies | 19% ± 2% | |
GABAergic neuron | 3 studies | 34% ± 7% | |
glutamatergic neuron | 3 studies | 38% ± 7% | |
macrophage | 3 studies | 22% ± 3% | |
oligodendrocyte | 3 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3460.87 | 1445 / 1445 | 100% | 20.94 | 183 / 183 |
prostate | 100% | 6411.60 | 245 / 245 | 100% | 37.91 | 502 / 502 |
thymus | 100% | 5099.80 | 653 / 653 | 100% | 18.70 | 604 / 605 |
ovary | 100% | 4385.23 | 180 / 180 | 100% | 18.17 | 429 / 430 |
lung | 100% | 4797.12 | 578 / 578 | 100% | 16.89 | 1152 / 1155 |
stomach | 100% | 3192.59 | 359 / 359 | 100% | 14.27 | 285 / 286 |
intestine | 100% | 4603.28 | 966 / 966 | 100% | 12.88 | 525 / 527 |
skin | 100% | 3401.37 | 1809 / 1809 | 100% | 14.64 | 470 / 472 |
uterus | 100% | 5222.54 | 170 / 170 | 100% | 15.26 | 457 / 459 |
breast | 100% | 4225.38 | 459 / 459 | 99% | 21.85 | 1112 / 1118 |
pancreas | 100% | 2923.70 | 328 / 328 | 99% | 14.71 | 177 / 178 |
bladder | 100% | 4456.19 | 21 / 21 | 99% | 14.77 | 501 / 504 |
brain | 99% | 2389.68 | 2616 / 2642 | 100% | 18.97 | 705 / 705 |
kidney | 100% | 3021.33 | 89 / 89 | 98% | 11.68 | 883 / 901 |
adrenal gland | 100% | 2894.90 | 258 / 258 | 97% | 10.29 | 224 / 230 |
liver | 100% | 2101.91 | 226 / 226 | 89% | 6.81 | 360 / 406 |
adipose | 100% | 3494.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 13.57 | 29 / 29 |
spleen | 100% | 6800.06 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 13.96 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.85 | 1 / 1 |
blood vessel | 100% | 4075.17 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2269.71 | 802 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 7161.60 | 927 / 929 | 0% | 0 | 0 / 0 |
heart | 99% | 1827.70 | 851 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 12.47 | 79 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0070822 | Cellular component | Sin3-type complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0017053 | Cellular component | transcription repressor complex |
GO_0005634 | Cellular component | nucleus |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0001222 | Molecular function | transcription corepressor binding |
GO_0005515 | Molecular function | protein binding |
GO_0035091 | Molecular function | phosphatidylinositol binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | PHF12 |
Protein name | PHD finger protein 12 PHD finger protein 12 (PHD factor 1) (Pf1) |
Synonyms | KIAA1523 |
Description | FUNCTION: Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail . SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules . SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 . SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription . May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA . May also play a role in ribosomal biogenesis (By similarity). . |
Accessions | K7EMX6 K7EJY3 ENST00000589176.1 C9J9G2 J3QQU3 Q96QT6 ENST00000579036.2 K7ENU0 Q0VAI6 ENST00000582853.5 ENST00000583747.1 ENST00000584236.1 ENST00000584822.1 ENST00000584685.1 ENST00000583524.5 ENST00000268756.7 [Q96QT6-2] K7EJN7 K7EQP5 K7EJ43 ENST00000578900.6 ENST00000577226.5 [Q96QT6-5] K7EPF7 ENST00000378879.7 K7ERZ4 ENST00000332830.9 [Q96QT6-1] |