PHF12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0070822Cellular componentSin3-type complex
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePHF12
Protein namePHD finger protein 12
PHD finger protein 12 (PHD factor 1) (Pf1)
SynonymsKIAA1523
DescriptionFUNCTION: Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail . SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules . SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 . SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription . May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA . May also play a role in ribosomal biogenesis (By similarity). .

AccessionsK7EMX6
K7EJY3
ENST00000589176.1
C9J9G2
J3QQU3
Q96QT6
ENST00000579036.2
K7ENU0
Q0VAI6
ENST00000582853.5
ENST00000583747.1
ENST00000584236.1
ENST00000584822.1
ENST00000584685.1
ENST00000583524.5
ENST00000268756.7 [Q96QT6-2]
K7EJN7
K7EQP5
K7EJ43
ENST00000578900.6
ENST00000577226.5 [Q96QT6-5]
K7EPF7
ENST00000378879.7
K7ERZ4
ENST00000332830.9 [Q96QT6-1]