RLIM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0060816Biological processrandom inactivation of X chromosome
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0017053Cellular componenttranscription repressor complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRLIM
Protein nameAlternative protein RLIM (HCG1811491)
E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)
SynonymshCG_1811491
RNF12
DescriptionFUNCTION: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. .

AccessionsL0R533
Q9NVW2
ENST00000332687.11 [Q9NVW2-1]
ENST00000349225.2 [Q9NVW2-1]