Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 21% ± 4% | |
classical monocyte | 5 studies | 19% ± 2% | |
neuron | 4 studies | 19% ± 3% | |
epithelial cell | 4 studies | 32% ± 13% | |
GABAergic neuron | 4 studies | 30% ± 11% | |
non-classical monocyte | 3 studies | 19% ± 4% | |
conventional dendritic cell | 3 studies | 46% ± 37% | |
hematopoietic precursor cell | 3 studies | 19% ± 2% | |
myeloid cell | 3 studies | 20% ± 2% | |
ciliated cell | 3 studies | 26% ± 6% | |
basal cell | 3 studies | 48% ± 36% | |
dendritic cell | 3 studies | 51% ± 32% | |
glutamatergic neuron | 3 studies | 44% ± 12% | |
oligodendrocyte precursor cell | 3 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 27% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2884.36 | 1445 / 1445 | 100% | 29.33 | 183 / 183 |
lung | 100% | 4810.25 | 578 / 578 | 100% | 20.83 | 1155 / 1155 |
breast | 100% | 4013.34 | 459 / 459 | 100% | 29.09 | 1117 / 1118 |
brain | 100% | 3343.48 | 2636 / 2642 | 100% | 24.10 | 705 / 705 |
ovary | 100% | 3692.26 | 180 / 180 | 100% | 14.74 | 429 / 430 |
adrenal gland | 100% | 4124.64 | 258 / 258 | 100% | 24.82 | 229 / 230 |
thymus | 100% | 3438.83 | 653 / 653 | 100% | 20.07 | 602 / 605 |
uterus | 100% | 3240.78 | 170 / 170 | 99% | 19.59 | 456 / 459 |
stomach | 100% | 2279.91 | 359 / 359 | 99% | 21.58 | 284 / 286 |
prostate | 100% | 3091.56 | 245 / 245 | 99% | 24.58 | 498 / 502 |
bladder | 100% | 2744.52 | 21 / 21 | 99% | 16.97 | 498 / 504 |
intestine | 100% | 2568.03 | 966 / 966 | 98% | 18.65 | 519 / 527 |
kidney | 100% | 2361.18 | 89 / 89 | 98% | 17.34 | 887 / 901 |
pancreas | 98% | 1314.36 | 323 / 328 | 98% | 17.00 | 175 / 178 |
skin | 100% | 4158.08 | 1809 / 1809 | 96% | 22.52 | 454 / 472 |
liver | 100% | 1374.02 | 225 / 226 | 79% | 6.96 | 320 / 406 |
adipose | 100% | 4229.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3307.34 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 11.69 | 29 / 29 |
muscle | 100% | 2169.68 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2862.19 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.13 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.25 | 1 / 1 |
heart | 97% | 2193.76 | 836 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 3076.18 | 893 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 11.56 | 71 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0060816 | Biological process | random inactivation of X chromosome |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0017053 | Cellular component | transcription repressor complex |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0046872 | Molecular function | metal ion binding |
Gene name | RLIM |
Protein name | Alternative protein RLIM (HCG1811491) E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) |
Synonyms | hCG_1811491 RNF12 |
Description | FUNCTION: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. . |
Accessions | L0R533 Q9NVW2 ENST00000332687.11 [Q9NVW2-1] ENST00000349225.2 [Q9NVW2-1] |