ZMYND8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_1902952Biological processpositive regulation of dendritic spine maintenance
GO_1902897Biological processregulation of postsynaptic density protein 95 clustering
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0098815Biological processmodulation of excitatory postsynaptic potential
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0060999Biological processpositive regulation of dendritic spine development
GO_0071168Biological processprotein localization to chromatin
GO_0030336Biological processnegative regulation of cell migration
GO_0007399Biological processnervous system development
GO_0005730Cellular componentnucleolus
GO_0043197Cellular componentdendritic spine
GO_0043198Cellular componentdendritic shaft
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0019904Molecular functionprotein domain specific binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZMYND8
Protein nameMYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8)
Zinc finger MYND-type containing 8
ZMYND8 protein
SynonymsPRKCBP1
KIAA1125
RACK7
DescriptionFUNCTION: Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) . May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac . May also act as a transcriptional corepressor for KDM5C and EZH2 . Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination . Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters . Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression . Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform . Suppresses breast cancer, and prostate cancer cell invasion and metastasis . .

AccessionsENST00000352431.6 [Q9ULU4-12]
ENST00000617418.4
ENST00000311275.11 [Q9ULU4-1]
ENST00000355972.8 [Q9ULU4-11]
A0A087WV57
ENST00000262975.8 [Q9ULU4-9]
ENST00000536340.5 [Q9ULU4-19]
Q5TH12
Q9ULU4
ENST00000471951.7 [Q9ULU4-7]
ENST00000372023.7 [Q9ULU4-23]
ENST00000360911.7 [Q9ULU4-14]
ENST00000396281.8 [Q9ULU4-20]
ENST00000461685.5 [Q9ULU4-13]
ENST00000441977.1
ENST00000458360.6 [Q9ULU4-17]
Q5TH07
ENST00000446994.6 [Q9ULU4-11]
ENST00000611941.4
ENST00000467200.6
ENST00000435836.5
A6H8Y8
ENST00000619049.4
A0A087WVZ6
Q569J9
ENST00000446894.5
ENST00000540497.5 [Q9ULU4-18]
A0A087WYS3
Q5TH08
H7C4X9