Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 35 studies | 38% ± 13% | |
| endothelial cell of artery | 14 studies | 45% ± 18% | |
| capillary endothelial cell | 14 studies | 43% ± 14% | |
| vein endothelial cell | 7 studies | 19% ± 3% | |
| endothelial cell of vascular tree | 7 studies | 31% ± 18% | |
| plasmacytoid dendritic cell | 6 studies | 27% ± 13% | |
| glomerular endothelial cell | 4 studies | 59% ± 16% | |
| pericyte | 3 studies | 49% ± 20% | |
| endothelial cell of sinusoid | 3 studies | 41% ± 15% |
Insufficient scRNA-seq data for expression of NOTCH4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 5893.59 | 653 / 653 | 98% | 14.30 | 591 / 605 |
| breast | 100% | 11900.50 | 459 / 459 | 97% | 8.52 | 1080 / 1118 |
| adrenal gland | 98% | 2683.84 | 252 / 258 | 97% | 14.60 | 224 / 230 |
| lung | 100% | 11636.17 | 578 / 578 | 93% | 6.80 | 1074 / 1155 |
| prostate | 99% | 4574.88 | 242 / 245 | 93% | 5.73 | 467 / 502 |
| bladder | 100% | 3207.05 | 21 / 21 | 90% | 5.30 | 456 / 504 |
| kidney | 100% | 5664.35 | 89 / 89 | 90% | 27.36 | 811 / 901 |
| esophagus | 95% | 2659.59 | 1371 / 1445 | 94% | 8.48 | 172 / 183 |
| brain | 85% | 1499.90 | 2254 / 2642 | 100% | 11.49 | 705 / 705 |
| stomach | 94% | 1914.96 | 336 / 359 | 91% | 6.61 | 261 / 286 |
| intestine | 93% | 2228.59 | 897 / 966 | 90% | 5.24 | 473 / 527 |
| uterus | 100% | 5319.03 | 170 / 170 | 73% | 4.13 | 333 / 459 |
| skin | 59% | 1173.02 | 1060 / 1809 | 95% | 5.79 | 449 / 472 |
| ovary | 74% | 1664.81 | 134 / 180 | 79% | 3.40 | 338 / 430 |
| pancreas | 50% | 697.28 | 165 / 328 | 98% | 9.77 | 175 / 178 |
| liver | 54% | 863.34 | 121 / 226 | 91% | 5.57 | 371 / 406 |
| adipose | 100% | 12368.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.77 | 1 / 1 |
| heart | 100% | 4836.84 | 859 / 861 | 0% | 0 | 0 / 0 |
| spleen | 99% | 2460.19 | 239 / 241 | 0% | 0 | 0 / 0 |
| muscle | 95% | 1857.03 | 762 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 83% | 3.00 | 24 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 4.00 | 35 / 45 |
| eye | 0% | 0 | 0 / 0 | 76% | 2.41 | 61 / 80 |
| blood vessel | 72% | 1742.43 | 967 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 13.57 | 13 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030879 | Biological process | mammary gland development |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0030097 | Biological process | hemopoiesis |
| GO_0001709 | Biological process | cell fate determination |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0051152 | Biological process | positive regulation of smooth muscle cell differentiation |
| GO_0045602 | Biological process | negative regulation of endothelial cell differentiation |
| GO_0042060 | Biological process | wound healing |
| GO_0007221 | Biological process | positive regulation of transcription of Notch receptor target |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0001944 | Biological process | vasculature development |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0001763 | Biological process | morphogenesis of a branching structure |
| GO_0030154 | Biological process | cell differentiation |
| GO_0060354 | Biological process | negative regulation of cell adhesion molecule production |
| GO_0045596 | Biological process | negative regulation of cell differentiation |
| GO_2000048 | Biological process | negative regulation of cell-cell adhesion mediated by cadherin |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0009986 | Cellular component | cell surface |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000987 | Molecular function | cis-regulatory region sequence-specific DNA binding |
| GO_0005112 | Molecular function | Notch binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NOTCH4 |
| Protein name | NOTCH4 (Neurogenic locus notch homolog protein 4) NOTCH4 protein NOTCH4 Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain] |
| Synonyms | INT3 |
| Description | FUNCTION: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). . |
| Accessions | Q99466 ENST00000375023.3 [Q99466-1] ENST00000454571.2 Q6P3V5 A0A1U9X989 ENST00000439349.2 ENST00000425600.1 A0A1U9X986 A0A140T9R5 ENST00000437843.2 ENST00000383264.4 A0A140T8Y6 ENST00000457094.2 [Q99466-1] |
