FRK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006468Biological processprotein phosphorylation
GO_0030154Biological processcell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0045087Biological processinnate immune response
GO_0035578Cellular componentazurophil granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005576Cellular componentextracellular region
GO_0035580Cellular componentspecific granule lumen
GO_0005634Cellular componentnucleus
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFRK
Protein nameTyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
SynonymsRAK
PTK5
DescriptionFUNCTION: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. .

AccessionsENST00000606080.2 [P42685-1]
P42685