ZBTB49 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZBTB49 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZBTB49 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0002682Biological processregulation of immune system process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001817Biological processregulation of cytokine production
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0001223Molecular functiontranscription coactivator binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZBTB49
Protein nameZinc finger and BTB domain-containing protein 49 (Zinc finger protein 509)
Zinc finger and BTB domain containing 49
SynonymsZNF509
DescriptionFUNCTION: Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. .; FUNCTION: [Isoform 1]: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive). .; FUNCTION: [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter. .

AccessionsH0Y8P2
ENST00000337872.9 [Q6ZSB9-1]
ENST00000503703.5
H0YAD4
D6RB16
Q6ZSB9
ENST00000515012.5
ENST00000511458.1
ENST00000504302.1
D6RJ00
ENST00000502918.1
D6RC96