DLX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DLX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DLX2 at tissue level.

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0009790Biological processembryo development
GO_0048715Biological processnegative regulation of oligodendrocyte differentiation
GO_0009954Biological processproximal/distal pattern formation
GO_0021766Biological processhippocampus development
GO_0007219Biological processNotch signaling pathway
GO_0021879Biological processforebrain neuron differentiation
GO_1902871Biological processpositive regulation of amacrine cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0021544Biological processsubpallium development
GO_0021772Biological processolfactory bulb development
GO_0046533Biological processnegative regulation of photoreceptor cell differentiation
GO_0045597Biological processpositive regulation of cell differentiation
GO_0030154Biological processcell differentiation
GO_0048709Biological processoligodendrocyte differentiation
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0007420Biological processbrain development
GO_0048755Biological processbranching morphogenesis of a nerve
GO_0014016Biological processneuroblast differentiation
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0051216Biological processcartilage development
GO_0021893Biological processcerebral cortex GABAergic interneuron fate commitment
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDLX2
Protein nameDistal-less homeobox 2 (cDNA FLJ75693, highly similar to Homo sapiens distal-less homeo box 2 (DLX2), mRNA)
Distal-less homeobox 2 isoform A
Homeobox protein DLX-2
SynonymshCG_16788
DescriptionFUNCTION: Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis (By similarity). .

AccessionsQ53QU7
ENST00000466293.2 [Q07687-2]
ENST00000234198.9 [Q07687-1]
Q07687
X5D7D8