ALX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ALX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALX1 at tissue level.

III. Associated gene sets

GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0048704Biological processembryonic skeletal system morphogenesis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding

IV. Literature review

[source]
Gene nameALX1
Protein nameALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1)
SynonymsCART1
DescriptionFUNCTION: Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes . Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival . May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 . .

AccessionsENST00000316824.4
Q15699