MAGEA6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAGEA6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAGEA6 at tissue level.

III. Associated gene sets

GO_0010507Biological processnegative regulation of autophagy
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0005575Cellular componentcellular_component
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMAGEA6
Protein nameMelanoma-associated antigen 6 (Cancer/testis antigen 1.6) (CT1.6) (MAGE-6 antigen) (MAGE3B antigen)
MAGEA6 protein
MAGE family member A6
SynonymsMAGE6
DescriptionFUNCTION: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy . May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex . May play a role in tumor transformation or aspects of tumor progression . In vitro promotes cell viability in melanoma cell lines . .

AccessionsP43360
ENST00000616035.4
E7EUF2
ENST00000457643.1
ENST00000710006.1
E7ETG4
ENST00000412733.1
ENST00000329342.10
Q6FGT7
Q6FHI5
ENST00000710007.1