PCNA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044849Biological processestrous cycle
GO_0032355Biological processresponse to estradiol
GO_1902990Biological processmitotic telomere maintenance via semi-conservative replication
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0030855Biological processepithelial cell differentiation
GO_0007507Biological processheart development
GO_0006287Biological processbase-excision repair, gap-filling
GO_0034644Biological processcellular response to UV
GO_0045739Biological processpositive regulation of DNA repair
GO_1900264Biological processpositive regulation of DNA-directed DNA polymerase activity
GO_0032077Biological processpositive regulation of deoxyribonuclease activity
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0046686Biological processresponse to cadmium ion
GO_0071548Biological processresponse to dexamethasone
GO_0031297Biological processreplication fork processing
GO_0097421Biological processliver regeneration
GO_0006272Biological processleading strand elongation
GO_0045740Biological processpositive regulation of DNA replication
GO_0019985Biological processtranslesion synthesis
GO_0006298Biological processmismatch repair
GO_1902065Biological processresponse to L-glutamate
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0043596Cellular componentnuclear replication fork
GO_0043626Cellular componentPCNA complex
GO_0070557Cellular componentPCNA-p21 complex
GO_0005813Cellular componentcentrosome
GO_0005657Cellular componentreplication fork
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0005652Cellular componentnuclear lamina
GO_0016604Cellular componentnuclear body
GO_0030894Cellular componentreplisome
GO_0000781Cellular componentchromosome, telomeric region
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0003682Molecular functionchromatin binding
GO_0030337Molecular functionDNA polymerase processivity factor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0070182Molecular functionDNA polymerase binding
GO_0032405Molecular functionMutLalpha complex binding
GO_0042802Molecular functionidentical protein binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0032139Molecular functiondinucleotide insertion or deletion binding
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0000701Molecular functionpurine-specific mismatch base pair DNA N-glycosylase activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene namePCNA
Protein nameProliferating cell nuclear antigen
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Truncated proliferating cell nuclear antigen
Synonyms
DescriptionFUNCTION: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand . Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways . Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion . .

FUNCTION: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. .

FUNCTION: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. .

AccessionsQ6FHF5
Q7Z6A1
Q7Z6A0
ENST00000379143.10
P12004
ENST00000379160.3
Q6FI35
Q7Z6A3
Q7Z6A2