CTCF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071459Biological processprotein localization to chromosome, centromeric region
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0070602Biological processregulation of centromeric sister chromatid cohesion
GO_0007059Biological processchromosome segregation
GO_0010628Biological processpositive regulation of gene expression
GO_0071514Biological processgenomic imprinting
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0140588Biological processchromatin looping
GO_0040029Biological processepigenetic regulation of gene expression
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000775Cellular componentchromosome, centromeric region
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0000793Cellular componentcondensed chromosome
GO_0001673Cellular componentmale germ cell nucleus
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0001221Molecular functiontranscription coregulator binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0140587Molecular functionchromatin loop anchoring activity
GO_0043035Molecular functionchromatin insulator sequence binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTCF
Protein nameCCCTC-binding factor
Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog)
Synonyms
DescriptionFUNCTION: Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin . Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina . Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers . Plays a critical role in the epigenetic regulation . Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus . On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (By similarity). Regulates asynchronous replication of IGF2/H19 (By similarity). Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones . Inversely, binding to target sites is prevented by CpG methylation . Plays an important role in chromatin remodeling . Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping . Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription . When bound to chromatin, it provides an anchor point for nucleosomes positioning . Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation . May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation . Involved in sister chromatid cohesion . Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites . Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis . Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene . Also binds to the PLK and PIM1 promoters . Acts as a transcriptional activator of APP . Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression . Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor . .

AccessionsENST00000646771.1
ENST00000644753.1 [P49711-1]
A0A2R8YFL0
ENST00000642819.1 [P49711-1]
ENST00000644852.1
ENST00000645306.1
A0A2R8Y6Z6
A0A2R8Y595
P49711
ENST00000646076.1 [P49711-1]
ENST00000401394.6 [P49711-2]
ENST00000642847.1
ENST00000264010.10 [P49711-1]
ENST00000645699.1 [P49711-1]
A0A2R8Y6C1
ENST00000643892.1