ZNF568 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060669Biological processembryonic placenta morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001701Biological processin utero embryonic development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameZNF568
Protein nameZNF568 protein
Zinc finger protein 568
Synonyms
DescriptionFUNCTION: Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as a direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells. .

FUNCTION: May be involved in transcriptional regulation. .

AccessionsA0A994J5R8
ENST00000433993.6
A0A994J7Z8
C9K0F2
ENST00000706169.1
A0A994J5D8
A2VDJ6
ENST00000706165.1
C9JLX5
ENST00000706166.1
ENST00000586353.6
A0A994J5R3
ENST00000706168.1
ENST00000587857.6
A0A994J7M0
ENST00000706170.1 [Q3ZCX4-1]
ENST00000706173.1
ENST00000706167.1
ENST00000706172.1
C9JXQ5
ENST00000706171.1
Q96AZ9
K7ELK8
ENST00000592567.1
Q3ZCX4
A0A0C4DGP9
ENST00000333987.12 [Q3ZCX4-1]
K7EL97
A0A994J7L7
ENST00000444991.6
ENST00000427117.6
ENST00000587857.6 [Q3ZCX4-2]
ENST00000588596.1
K7EKY2
ENST00000587130.6 [Q3ZCX4-2]
C9JZ58
ENST00000455817.5
ENST00000455427.7 [Q3ZCX4-3]
ENST00000587130.6
A0A1Y8EHF7
ENST00000415168.5 [Q3ZCX4-2]