Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 9 studies | 24% ± 7% | |
| type I pneumocyte | 7 studies | 19% ± 2% | |
| glutamatergic neuron | 6 studies | 35% ± 23% | |
| epithelial cell | 5 studies | 28% ± 3% | |
| GABAergic neuron | 5 studies | 35% ± 22% | |
| astrocyte | 5 studies | 30% ± 12% | |
| macrophage | 4 studies | 19% ± 3% | |
| oligodendrocyte | 4 studies | 22% ± 5% | |
| retinal bipolar neuron | 3 studies | 19% ± 0% | |
| microglial cell | 3 studies | 20% ± 4% | |
| retinal ganglion cell | 3 studies | 37% ± 14% | |
| ciliated cell | 3 studies | 25% ± 5% | |
| amacrine cell | 3 studies | 16% ± 1% | |
| fibroblast | 3 studies | 22% ± 5% | |
| adipocyte | 3 studies | 18% ± 3% | |
| interneuron | 3 studies | 46% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 10476.14 | 245 / 245 | 100% | 79.93 | 502 / 502 |
| thymus | 100% | 14134.25 | 653 / 653 | 100% | 137.32 | 605 / 605 |
| brain | 100% | 10123.76 | 2641 / 2642 | 100% | 88.60 | 704 / 705 |
| breast | 100% | 9898.69 | 459 / 459 | 100% | 71.04 | 1114 / 1118 |
| kidney | 100% | 6473.79 | 89 / 89 | 99% | 71.38 | 895 / 901 |
| adrenal gland | 100% | 10222.41 | 258 / 258 | 99% | 76.38 | 228 / 230 |
| esophagus | 100% | 11021.97 | 1445 / 1445 | 99% | 56.55 | 181 / 183 |
| skin | 100% | 7315.83 | 1808 / 1809 | 99% | 50.38 | 467 / 472 |
| lung | 100% | 9123.52 | 578 / 578 | 99% | 53.31 | 1142 / 1155 |
| ovary | 100% | 13725.09 | 180 / 180 | 99% | 52.92 | 425 / 430 |
| uterus | 100% | 13135.52 | 170 / 170 | 98% | 42.23 | 452 / 459 |
| bladder | 100% | 12457.38 | 21 / 21 | 98% | 40.41 | 493 / 504 |
| stomach | 100% | 6727.64 | 359 / 359 | 96% | 38.78 | 275 / 286 |
| pancreas | 96% | 3772.46 | 316 / 328 | 98% | 52.01 | 175 / 178 |
| intestine | 100% | 10317.32 | 964 / 966 | 94% | 31.88 | 493 / 527 |
| adipose | 100% | 9806.29 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 12973.03 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 68.62 | 80 / 80 |
| spleen | 100% | 6571.94 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 50.21 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 14.85 | 1 / 1 |
| muscle | 100% | 5375.05 | 799 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 7201.29 | 849 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 30.78 | 28 / 29 |
| peripheral blood | 63% | 2658.89 | 587 / 929 | 0% | 0 | 0 / 0 |
| liver | 19% | 370.91 | 42 / 226 | 42% | 12.29 | 172 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006974 | Biological process | DNA damage response |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005694 | Cellular component | chromosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0008327 | Molecular function | methyl-CpG binding |
| GO_0010428 | Molecular function | methyl-CpNpG binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ZBTB4 |
| Protein name | Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) ZBTB4 protein |
| Synonyms | KIAA1538 |
| Description | FUNCTION: Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA . Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). . |
| Accessions | ENST00000311403.4 ENST00000380599.9 ENST00000639962.1 Q9P1Z0 A2RRQ0 ENST00000639670.2 |