GFI1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GFI1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GFI1 at tissue level.

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010956Biological processnegative regulation of calcidiol 1-monooxygenase activity
GO_0006974Biological processDNA damage response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0070105Biological processpositive regulation of interleukin-6-mediated signaling pathway
GO_0010977Biological processnegative regulation of neuron projection development
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0034121Biological processregulation of toll-like receptor signaling pathway
GO_0010957Biological processnegative regulation of vitamin D biosynthetic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0017053Cellular componenttranscription repressor complex
GO_0016363Cellular componentnuclear matrix
GO_0016604Cellular componentnuclear body
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0140767Molecular functionenzyme-substrate adaptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGFI1
Protein nameGrowth factor independent 1 transcriptional repressor
Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163)
SynonymsZNF163
DescriptionFUNCTION: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells. .

AccessionsENST00000696670.1
ENST00000696669.1
ENST00000427103.6
A0A8Q3SJ16
ENST00000696667.1
A0A8Q3SIQ6
A0A8Q3SIW2
ENST00000483490.1
ENST00000370332.5
ENST00000294702.6
Q99684