TBXT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TBXT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TBXT at tissue level.

III. Associated gene sets

GO_0007498Biological processmesoderm development
GO_0001708Biological processcell fate specification
GO_0090009Biological processprimitive streak formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0008595Biological processanterior/posterior axis specification, embryo
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0001707Biological processmesoderm formation
GO_0060379Biological processcardiac muscle cell myoblast differentiation
GO_0001756Biological processsomitogenesis
GO_0003007Biological processheart morphogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity

IV. Literature review

[source]
Gene nameTBXT
Protein nameT-box transcription factor T (Brachyury protein) (Protein T)
Troponin T protein
SynonymsT
troponin
DescriptionFUNCTION: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site. .

AccessionsENST00000461348.2
ENST00000366871.7 [O15178-2]
J3KP65
ENST00000366876.7
V9H0A7
ENST00000296946.6 [O15178-1]
O15178
H0YM91