TRIM27 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0016925Biological processprotein sumoylation
GO_0007283Biological processspermatogenesis
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0045087Biological processinnate immune response
GO_0002820Biological processnegative regulation of adaptive immune response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090281Biological processnegative regulation of calcium ion import
GO_0032480Biological processnegative regulation of type I interferon production
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0034314Biological processArp2/3 complex-mediated actin nucleation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0051127Biological processpositive regulation of actin nucleation
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0010507Biological processnegative regulation of autophagy
GO_0032729Biological processpositive regulation of type II interferon production
GO_0044790Biological processsuppression of viral release by host
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0032897Biological processnegative regulation of viral transcription
GO_0005730Cellular componentnucleolus
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019789Molecular functionSUMO transferase activity
GO_0003676Molecular functionnucleic acid binding
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM27
Protein nameTripartite motif containing 27 (Zinc finger protein RFP)
Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
Zinc finger protein RFP
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
SynonymsRNF76
RFP
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy . Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly . Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis . In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation . Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome . Alternatively, facilitates mitophagy via stabilization of active TBK1 . Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 . During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy . .; FUNCTION: (Microbial infection) Positively regulates hepatitis C virus replication by suppressing type I IFN response during infection. .

AccessionsH0Y551
P14373
ENST00000437415.5
A0A140T9N6
ENST00000417660.6 [P14373-2]
ENST00000377194.7 [P14373-2]
ENST00000430208.1
ENST00000414543.5
A0A0G2JIZ4
ENST00000400720.7 [P14373-1]
ENST00000435528.6 [P14373-1]
ENST00000417993.1
ENST00000430891.1
ENST00000445968.5
ENST00000443804.1
ENST00000452265.6 [P14373-2]
ENST00000412687.6 [P14373-2]
A0A140T9Q6
ENST00000440169.5
ENST00000377199.4 [P14373-1]
ENST00000431123.6 [P14373-1]
ENST00000437160.6 [P14373-1]
ENST00000453610.1
ENST00000436621.1
A0A140T9B9
ENST00000455861.5
ENST00000427689.6 [P14373-2]
A0A140T9V9
ENST00000437383.1