SUV39H1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SUV39H1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SUV39H1 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0097009Biological processenergy homeostasis
GO_0042149Biological processcellular response to glucose starvation
GO_0045786Biological processnegative regulation of cell cycle
GO_0032259Biological processmethylation
GO_0000183Biological processrDNA heterochromatin formation
GO_0006974Biological processDNA damage response
GO_0046015Biological processregulation of transcription by glucose
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007623Biological processcircadian rhythm
GO_0030154Biological processcell differentiation
GO_0006364Biological processrRNA processing
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0071456Biological processcellular response to hypoxia
GO_0044725Biological processepigenetic programming in the zygotic pronuclei
GO_0000775Cellular componentchromosome, centromeric region
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0061773Cellular componenteNoSc complex
GO_0000792Cellular componentheterochromatin
GO_0005654Cellular componentnucleoplasm
GO_0005677Cellular componentchromatin silencing complex
GO_0005652Cellular componentnuclear lamina
GO_0033553Cellular componentrDNA heterochromatin
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005634Cellular componentnucleus
GO_0140949Molecular functionhistone H3K9 trimethyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0046974Molecular functionhistone H3K9 methyltransferase activity
GO_0042054Molecular functionhistone methyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0008757Molecular functionS-adenosylmethionine-dependent methyltransferase activity

IV. Literature review

[source]
Gene nameSUV39H1
Protein nameHistone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
SynonymsKMT1A
SUV39H
DescriptionFUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. .; FUNCTION: (Microbial infection) Plays a role in defense against mycobacterial infections. Methylates M.tuberculosis HupB on 'Lys-140', probably methylates HupB of M.bovis also. Methylation has an inhibitory effect on mycobacterial growth in the host. Macrophages expressing about 60% SUV39H1 are slightly more susceptible to M.bovis or M.tuberculosis infection. Chaetocin (an inhibitor of this enzyme) increases macrophage survival of M.tuberculosis. This protein inhibits biofilm formation by M.tuberculosis via 'Lys-140' trimethylation. .

AccessionsENST00000337852.10 [O43463-2]
O43463
ENST00000376687.4 [O43463-1]