TXN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	39 studies	57% ± 19%	Explore
endothelial cell	37 studies	51% ± 19%	Explore
macrophage	36 studies	52% ± 22%	Explore
natural killer cell	34 studies	34% ± 14%	Explore
B cell	31 studies	25% ± 10%	Explore
CD8-positive, alpha-beta T cell	31 studies	43% ± 20%	Explore
conventional dendritic cell	30 studies	59% ± 14%	Explore
T cell	29 studies	42% ± 17%	Explore
CD4-positive, alpha-beta T cell	29 studies	40% ± 21%	Explore
pericyte	28 studies	53% ± 17%	Explore
plasmacytoid dendritic cell	27 studies	77% ± 16%	Explore
classical monocyte	26 studies	54% ± 17%	Explore
epithelial cell	26 studies	76% ± 18%	Explore
dendritic cell	25 studies	68% ± 24%	Explore
smooth muscle cell	25 studies	55% ± 14%	Explore
regulatory T cell	25 studies	44% ± 19%	Explore
mast cell	22 studies	51% ± 16%	Explore
endothelial cell of lymphatic vessel	22 studies	72% ± 17%	Explore
non-classical monocyte	22 studies	43% ± 16%	Explore
basal cell	22 studies	74% ± 18%	Explore
plasma cell	21 studies	54% ± 16%	Explore
monocyte	20 studies	51% ± 15%	Explore
connective tissue cell	19 studies	59% ± 18%	Explore
gamma-delta T cell	17 studies	34% ± 14%	Explore
ciliated cell	16 studies	81% ± 13%	Explore
mature NK T cell	15 studies	34% ± 9%	Explore
memory B cell	15 studies	25% ± 13%	Explore
myeloid cell	15 studies	59% ± 24%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	26% ± 7%	Explore
neutrophil	13 studies	47% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	25% ± 6%	Explore
capillary endothelial cell	13 studies	42% ± 16%	Explore
myofibroblast cell	13 studies	55% ± 11%	Explore
plasmablast	12 studies	58% ± 24%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	36% ± 18%	Explore
secretory cell	12 studies	74% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	34% ± 11%	Explore
vein endothelial cell	12 studies	54% ± 18%	Explore
endothelial cell of vascular tree	12 studies	72% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	30% ± 14%	Explore
endothelial cell of artery	11 studies	48% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	41% ± 22%	Explore
progenitor cell	10 studies	83% ± 13%	Explore
innate lymphoid cell	10 studies	40% ± 16%	Explore
goblet cell	10 studies	68% ± 17%	Explore
mesothelial cell	10 studies	55% ± 16%	Explore
mucosal invariant T cell	10 studies	32% ± 5%	Explore
type I pneumocyte	9 studies	59% ± 20%	Explore
type II pneumocyte	9 studies	66% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	36% ± 9%	Explore
abnormal cell	9 studies	57% ± 27%	Explore
club cell	8 studies	76% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	53% ± 25%	Explore
leukocyte	8 studies	46% ± 10%	Explore
neuron	8 studies	50% ± 22%	Explore
enterocyte	8 studies	66% ± 21%	Explore
alveolar macrophage	7 studies	67% ± 31%	Explore
ionocyte	7 studies	76% ± 18%	Explore
respiratory goblet cell	7 studies	82% ± 16%	Explore
mononuclear phagocyte	7 studies	48% ± 17%	Explore
epithelial cell of proximal tubule	7 studies	81% ± 9%	Explore
erythroblast	7 studies	52% ± 26%	Explore
IgA plasma cell	7 studies	34% ± 13%	Explore
IgG plasma cell	7 studies	29% ± 14%	Explore
hematopoietic stem cell	7 studies	77% ± 15%	Explore
erythrocyte	7 studies	49% ± 26%	Explore
T follicular helper cell	7 studies	25% ± 7%	Explore
CD4-positive helper T cell	6 studies	31% ± 11%	Explore
hematopoietic precursor cell	6 studies	68% ± 24%	Explore
kidney loop of Henle epithelial cell	6 studies	52% ± 9%	Explore
renal alpha-intercalated cell	6 studies	73% ± 7%	Explore
transit amplifying cell	6 studies	69% ± 28%	Explore
brush cell	6 studies	66% ± 27%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	50% ± 24%	Explore
exhausted T cell	5 studies	48% ± 21%	Explore
platelet	5 studies	23% ± 6%	Explore
monocyte-derived dendritic cell	5 studies	80% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	71% ± 16%	Explore
enteroendocrine cell	5 studies	77% ± 13%	Explore
intestinal crypt stem cell	5 studies	82% ± 21%	Explore
neuroendocrine cell	5 studies	79% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	65% ± 20%	Explore
intermediate monocyte	5 studies	65% ± 14%	Explore
granulocyte	5 studies	60% ± 21%	Explore
interneuron	5 studies	35% ± 25%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	45% ± 28%	Explore
deuterosomal cell	4 studies	82% ± 19%	Explore
duct epithelial cell	4 studies	82% ± 5%	Explore
pancreatic A cell	4 studies	73% ± 14%	Explore
type B pancreatic cell	4 studies	74% ± 12%	Explore
naive B cell	4 studies	28% ± 6%	Explore
podocyte	4 studies	70% ± 12%	Explore
retinal ganglion cell	4 studies	70% ± 27%	Explore
megakaryocyte	4 studies	42% ± 10%	Explore
pro-B cell	4 studies	44% ± 7%	Explore
amacrine cell	4 studies	35% ± 19%	Explore
astrocyte	4 studies	33% ± 13%	Explore
adventitial cell	4 studies	61% ± 11%	Explore
mucus secreting cell	4 studies	65% ± 13%	Explore
acinar cell	4 studies	66% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	85% ± 6%	Explore
inflammatory macrophage	4 studies	51% ± 26%	Explore
GABAergic neuron	4 studies	28% ± 5%	Explore
glutamatergic neuron	4 studies	40% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	74% ± 21%	Explore
glial cell	4 studies	40% ± 15%	Explore
hepatocyte	4 studies	66% ± 21%	Explore
keratinocyte	4 studies	85% ± 6%	Explore
T-helper 17 cell	4 studies	55% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	36% ± 9%	Explore
precursor cell	3 studies	82% ± 5%	Explore
squamous epithelial cell	3 studies	66% ± 21%	Explore
glomerular endothelial cell	3 studies	42% ± 6%	Explore
neural crest cell	3 studies	62% ± 7%	Explore
renal principal cell	3 studies	57% ± 7%	Explore
extravillous trophoblast	3 studies	92% ± 4%	Explore
placental villous trophoblast	3 studies	82% ± 13%	Explore
common myeloid progenitor	3 studies	62% ± 31%	Explore
lymphocyte	3 studies	75% ± 4%	Explore
Schwann cell	3 studies	64% ± 15%	Explore
immature B cell	3 studies	39% ± 27%	Explore
retina horizontal cell	3 studies	34% ± 15%	Explore
retinal cone cell	3 studies	41% ± 18%	Explore
retinal rod cell	3 studies	27% ± 10%	Explore
microglial cell	3 studies	25% ± 10%	Explore
serous secreting cell	3 studies	66% ± 6%	Explore
tissue-resident macrophage	3 studies	36% ± 14%	Explore
intraepithelial lymphocyte	3 studies	39% ± 12%	Explore
muscle cell	3 studies	49% ± 9%	Explore
oligodendrocyte	3 studies	24% ± 3%	Explore
myoepithelial cell	3 studies	71% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	74% ± 8%	Explore
pancreatic ductal cell	3 studies	90% ± 1%	Explore
oligodendrocyte precursor cell	3 studies	40% ± 17%	Explore
granulocyte monocyte progenitor cell	3 studies	67% ± 31%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 12%	Explore
melanocyte	3 studies	37% ± 2%	Explore
T-helper 1 cell	3 studies	61% ± 23%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	31% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	32% ± 12%	Explore
double negative thymocyte	3 studies	56% ± 25%	Explore
progenitor cell of mammary luminal epithelium	3 studies	75% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	37% ± 13%	Explore
lung	18 studies	60% ± 17%	Explore
intestine	13 studies	50% ± 20%	Explore
kidney	9 studies	54% ± 15%	Explore
eye	8 studies	32% ± 15%	Explore
brain	8 studies	31% ± 9%	Explore
bone marrow	7 studies	36% ± 18%	Explore
lymph node	7 studies	35% ± 20%	Explore
liver	7 studies	45% ± 16%	Explore
uterus	6 studies	60% ± 20%	Explore
pancreas	5 studies	68% ± 21%	Explore
placenta	4 studies	71% ± 16%	Explore
esophagus	4 studies	66% ± 17%	Explore
prostate	4 studies	69% ± 22%	Explore
skin	4 studies	71% ± 8%	Explore
breast	4 studies	69% ± 10%	Explore
ovary	3 studies	41% ± 8%	Explore
adipose	3 studies	24% ± 7%	Explore
adrenal gland	3 studies	46% ± 8%	Explore
thymus	3 studies	71% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	15293.11	1445 / 1445	100%	1029.84	183 / 183
stomach	100%	5997.84	359 / 359	100%	864.86	286 / 286
intestine	100%	6898.61	966 / 966	100%	971.34	526 / 527
bladder	100%	6015.95	21 / 21	100%	845.55	502 / 504
skin	100%	8629.51	1809 / 1809	100%	417.31	470 / 472
lung	100%	5908.01	576 / 578	100%	871.05	1154 / 1155
uterus	100%	3741.55	170 / 170	100%	1015.71	457 / 459
prostate	100%	4008.39	245 / 245	99%	536.39	498 / 502
breast	100%	4940.82	459 / 459	99%	620.59	1108 / 1118
liver	100%	5264.22	225 / 226	100%	802.17	404 / 406
thymus	100%	3634.93	651 / 653	99%	365.12	599 / 605
ovary	99%	2835.73	179 / 180	99%	414.60	425 / 430
adrenal gland	100%	4292.54	258 / 258	98%	331.12	225 / 230
kidney	100%	7877.52	89 / 89	98%	425.65	880 / 901
brain	99%	3855.71	2623 / 2642	95%	235.48	668 / 705
pancreas	95%	2327.59	310 / 328	99%	568.49	176 / 178
lymph node	0%	0	0 / 0	100%	786.57	29 / 29
spleen	100%	3688.16	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	1045.78	45 / 45
ureter	0%	0	0 / 0	100%	462.60	1 / 1
adipose	100%	4844.73	1202 / 1204	0%	0	0 / 0
blood vessel	100%	4908.54	1330 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	335.97	79 / 80
heart	91%	1944.55	780 / 861	0%	0	0 / 0
peripheral blood	89%	6301.71	825 / 929	0%	0	0 / 0
muscle	81%	1587.52	651 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045454	Biological process	cell redox homeostasis
GO_0046826	Biological process	negative regulation of protein export from nucleus
GO_0061692	Biological process	cellular detoxification of hydrogen peroxide
GO_0032148	Biological process	activation of protein kinase B activity
GO_2000170	Biological process	positive regulation of peptidyl-cysteine S-nitrosylation
GO_0009314	Biological process	response to radiation
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0071731	Biological process	response to nitric oxide
GO_0043388	Biological process	positive regulation of DNA binding
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0015035	Molecular function	protein-disulfide reductase activity
GO_0047134	Molecular function	protein-disulfide reductase (NAD(P)H) activity
GO_0004791	Molecular function	thioredoxin-disulfide reductase (NADPH) activity
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TXN
Protein name	Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx) Mitochondrial thioredoxin Thioredoxin
Synonyms	TRDX TRX TRX1
Description	FUNCTION: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions . Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity . Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity . .; FUNCTION: ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Accessions	ENST00000374517.6 [P10599-1] ENST00000374515.9 [P10599-2] H9ZYJ2 P10599 A0A1S5UZH5

TXN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review