TRIM33 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	30% ± 14%	Explore
glutamatergic neuron	11 studies	47% ± 26%	Explore
astrocyte	11 studies	37% ± 15%	Explore
oligodendrocyte precursor cell	11 studies	36% ± 15%	Explore
oligodendrocyte	11 studies	32% ± 12%	Explore
macrophage	10 studies	32% ± 11%	Explore
microglial cell	10 studies	31% ± 11%	Explore
GABAergic neuron	9 studies	46% ± 24%	Explore
epithelial cell	9 studies	37% ± 22%	Explore
ciliated cell	8 studies	26% ± 11%	Explore
fibroblast	8 studies	25% ± 9%	Explore
B cell	7 studies	21% ± 4%	Explore
T cell	7 studies	23% ± 7%	Explore
natural killer cell	7 studies	25% ± 6%	Explore
pericyte	7 studies	29% ± 14%	Explore
adipocyte	7 studies	22% ± 6%	Explore
type I pneumocyte	7 studies	23% ± 8%	Explore
neuron	6 studies	45% ± 13%	Explore
interneuron	6 studies	52% ± 23%	Explore
retina horizontal cell	6 studies	24% ± 9%	Explore
retinal cone cell	6 studies	24% ± 7%	Explore
dendritic cell	6 studies	25% ± 10%	Explore
smooth muscle cell	6 studies	23% ± 5%	Explore
basal cell	6 studies	31% ± 20%	Explore
type II pneumocyte	6 studies	22% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	21% ± 3%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 1%	Explore
retinal bipolar neuron	5 studies	21% ± 4%	Explore
myeloid cell	5 studies	27% ± 8%	Explore
amacrine cell	5 studies	27% ± 8%	Explore
CD8-positive, alpha-beta T cell	5 studies	20% ± 5%	Explore
mast cell	5 studies	23% ± 4%	Explore
endothelial cell of lymphatic vessel	5 studies	29% ± 6%	Explore
monocyte	5 studies	26% ± 6%	Explore
club cell	5 studies	26% ± 9%	Explore
classical monocyte	4 studies	24% ± 6%	Explore
non-classical monocyte	4 studies	25% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	21% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	23% ± 1%	Explore
granule cell	4 studies	32% ± 7%	Explore
retinal ganglion cell	4 studies	26% ± 5%	Explore
cardiac muscle cell	4 studies	19% ± 1%	Explore
lymphocyte	4 studies	33% ± 10%	Explore
respiratory goblet cell	4 studies	26% ± 12%	Explore
goblet cell	4 studies	31% ± 21%	Explore
hematopoietic precursor cell	3 studies	27% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
GABAergic interneuron	3 studies	35% ± 6%	Explore
glial cell	3 studies	24% ± 7%	Explore
progenitor cell	3 studies	28% ± 4%	Explore
squamous epithelial cell	3 studies	30% ± 20%	Explore
vein endothelial cell	3 studies	26% ± 15%	Explore
GABAergic amacrine cell	3 studies	29% ± 7%	Explore
Mueller cell	3 studies	24% ± 6%	Explore
OFF-bipolar cell	3 studies	26% ± 6%	Explore
ON-bipolar cell	3 studies	26% ± 6%	Explore
glycinergic amacrine cell	3 studies	28% ± 6%	Explore
retinal rod cell	3 studies	22% ± 0%	Explore
rod bipolar cell	3 studies	26% ± 7%	Explore
hepatocyte	3 studies	35% ± 15%	Explore
abnormal cell	3 studies	29% ± 14%	Explore
ependymal cell	3 studies	28% ± 12%	Explore
enteroendocrine cell	3 studies	23% ± 5%	Explore
leukocyte	3 studies	26% ± 7%	Explore
alveolar macrophage	3 studies	34% ± 9%	Explore
transit amplifying cell	3 studies	41% ± 31%	Explore
plasmacytoid dendritic cell	3 studies	17% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	37% ± 21%	Explore
lung	7 studies	22% ± 7%	Explore
eye	6 studies	27% ± 14%	Explore
peripheral blood	3 studies	25% ± 4%	Explore
heart	3 studies	18% ± 2%	Explore
liver	3 studies	35% ± 11%	Explore
intestine	3 studies	19% ± 3%	Explore
adipose	3 studies	23% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3372.68	1445 / 1445	100%	30.79	183 / 183
ovary	100%	4321.17	180 / 180	100%	22.37	430 / 430
lung	100%	3643.88	578 / 578	100%	18.85	1153 / 1155
brain	100%	2932.85	2637 / 2642	100%	20.33	705 / 705
prostate	100%	3715.39	245 / 245	100%	25.92	501 / 502
breast	100%	3990.69	459 / 459	100%	27.19	1114 / 1118
thymus	100%	4140.25	653 / 653	99%	19.19	601 / 605
bladder	100%	3925.90	21 / 21	99%	17.81	499 / 504
uterus	100%	4513.64	170 / 170	99%	18.12	454 / 459
pancreas	100%	2118.36	327 / 328	99%	14.17	176 / 178
stomach	100%	2782.29	359 / 359	98%	21.07	280 / 286
intestine	100%	3624.39	966 / 966	97%	15.91	511 / 527
kidney	100%	2356.60	89 / 89	96%	14.25	867 / 901
skin	100%	4374.44	1809 / 1809	94%	17.62	444 / 472
adrenal gland	100%	2844.09	258 / 258	90%	7.74	206 / 230
liver	100%	1578.18	226 / 226	86%	8.55	348 / 406
adipose	100%	3510.06	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3914.32	1335 / 1335	0%	0	0 / 0
spleen	100%	3305.53	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.42	45 / 45
ureter	0%	0	0 / 0	100%	13.87	1 / 1
muscle	100%	2050.74	801 / 803	0%	0	0 / 0
heart	95%	1567.65	819 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	11.54	27 / 29
peripheral blood	92%	2407.14	856 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	68%	6.55	54 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0017015	Biological process	regulation of transforming growth factor beta receptor signaling pathway
GO_0016567	Biological process	protein ubiquitination
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0070410	Molecular function	co-SMAD binding
GO_0003677	Molecular function	DNA binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0070412	Molecular function	R-SMAD binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	TRIM33
Protein name	Tripartite motif containing 33 E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)
Synonyms	KIAA1113 RFG7 TIF1G
Description	FUNCTION: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). .
Accessions	H0Y612 ENST00000448034.5 ENST00000358465.7 [Q9UPN9-1] Q9UPN9 ENST00000369543.6 [Q9UPN9-2]

TRIM33 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review