PRDM6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRDM6 at tissue level.

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0022008Biological processneurogenesis
GO_0032259Biological processmethylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0051151Biological processnegative regulation of smooth muscle cell differentiation
GO_0005634Cellular componentnucleus
GO_0140944Molecular functionhistone H4K20 monomethyltransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePRDM6
Protein namePutative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6)
PR/SET domain 6
SynonymsPFM3
DescriptionFUNCTION: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. .

AccessionsQ9NQX0
ENST00000407847.5 [Q9NQX0-3]
ENST00000434521.1
H7BZR2