EFNA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061098Biological processpositive regulation of protein tyrosine kinase activity
GO_0001525Biological processangiogenesis
GO_0048013Biological processephrin receptor signaling pathway
GO_0043535Biological processregulation of blood vessel endothelial cell migration
GO_1903051Biological processnegative regulation of proteolysis involved in protein catabolic process
GO_0003183Biological processmitral valve morphogenesis
GO_1902961Biological processpositive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO_0061002Biological processnegative regulation of dendritic spine morphogenesis
GO_0003180Biological processaortic valve morphogenesis
GO_0003199Biological processendocardial cushion to mesenchymal transition involved in heart valve formation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007267Biological processcell-cell signaling
GO_0045765Biological processregulation of angiogenesis
GO_0050730Biological processregulation of peptidyl-tyrosine phosphorylation
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_0014028Biological processnotochord formation
GO_0033628Biological processregulation of cell adhesion mediated by integrin
GO_0050821Biological processprotein stabilization
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0016477Biological processcell migration
GO_0007411Biological processaxon guidance
GO_0050770Biological processregulation of axonogenesis
GO_0070244Biological processnegative regulation of thymocyte apoptotic process
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0098552Cellular componentside of membrane
GO_0046875Molecular functionephrin receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEFNA1
Protein nameEphrin-A1
Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]
SynonymsEPLG1
hCG_1745153
TNFAIP4
LERK1
DescriptionFUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. .

FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. .

AccessionsP20827
A8K0M4
ENST00000368407.8 [P20827-1]
ENST00000368406.2 [P20827-2]