Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 5167.45 | 1445 / 1445 | 100% | 97.99 | 183 / 183 |
| ovary | 100% | 2561.42 | 180 / 180 | 100% | 69.27 | 430 / 430 |
| pancreas | 100% | 2200.62 | 328 / 328 | 100% | 68.48 | 178 / 178 |
| stomach | 100% | 3412.05 | 359 / 359 | 100% | 80.66 | 286 / 286 |
| skin | 100% | 2976.85 | 1808 / 1809 | 100% | 117.80 | 472 / 472 |
| intestine | 100% | 3967.11 | 966 / 966 | 100% | 72.95 | 526 / 527 |
| thymus | 100% | 3294.26 | 653 / 653 | 100% | 78.55 | 602 / 605 |
| prostate | 100% | 2749.62 | 245 / 245 | 99% | 44.30 | 499 / 502 |
| lung | 100% | 3920.21 | 577 / 578 | 99% | 56.12 | 1149 / 1155 |
| brain | 99% | 2376.24 | 2623 / 2642 | 100% | 55.22 | 705 / 705 |
| bladder | 100% | 3750.90 | 21 / 21 | 99% | 59.16 | 500 / 504 |
| breast | 100% | 3646.35 | 459 / 459 | 99% | 50.89 | 1106 / 1118 |
| uterus | 100% | 3222.44 | 170 / 170 | 99% | 67.73 | 454 / 459 |
| kidney | 100% | 2436.00 | 89 / 89 | 98% | 61.01 | 886 / 901 |
| adrenal gland | 100% | 1906.47 | 258 / 258 | 95% | 35.59 | 218 / 230 |
| liver | 54% | 415.61 | 121 / 226 | 54% | 26.04 | 220 / 406 |
| adipose | 100% | 3660.15 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 3096.35 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5473.46 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 67.41 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 42.89 | 1 / 1 |
| blood vessel | 100% | 3400.88 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1839.20 | 856 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 2228.98 | 898 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 40.20 | 77 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 31.64 | 26 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0030838 | Biological process | positive regulation of actin filament polymerization |
| GO_0048013 | Biological process | ephrin receptor signaling pathway |
| GO_0001771 | Biological process | immunological synapse formation |
| GO_0036493 | Biological process | positive regulation of translation in response to endoplasmic reticulum stress |
| GO_0030032 | Biological process | lamellipodium assembly |
| GO_0007165 | Biological process | signal transduction |
| GO_1902310 | Biological process | positive regulation of peptidyl-serine dephosphorylation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_1902237 | Biological process | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| GO_0060996 | Biological process | dendritic spine development |
| GO_0007172 | Biological process | signal complex assembly |
| GO_0007015 | Biological process | actin filament organization |
| GO_1903898 | Biological process | negative regulation of PERK-mediated unfolded protein response |
| GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
| GO_1903912 | Biological process | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation |
| GO_0042110 | Biological process | T cell activation |
| GO_0016477 | Biological process | cell migration |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0012506 | Cellular component | vesicle membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0035591 | Molecular function | signaling adaptor activity |
| GO_0030159 | Molecular function | signaling receptor complex adaptor activity |
| GO_0001784 | Molecular function | phosphotyrosine residue binding |
| GO_0008093 | Molecular function | cytoskeletal anchor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0030971 | Molecular function | receptor tyrosine kinase binding |
| Gene name | NCK2 |
| Protein name | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) NCK adaptor protein 2 NCK adaptor protein 2 isoform 1 Uncharacterized protein NCK2 |
| Synonyms | GRB4 |
| Description | FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. . |
| Accessions | ENST00000425756.1 ENST00000451463.6 E7ERP6 ENST00000522586.5 E7EPF5 O43639 ENST00000233154.9 Q53TG4 E9PEE2 Q53T91 A0A0S2Z4M6 ENST00000393348.6 ENST00000393349.2 |
