SHOX2 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SHOX2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	1000.61	457 / 459	91%	3.78	1022 / 1118
skin	86%	776.47	1553 / 1809	83%	4.95	391 / 472
uterus	30%	164.86	51 / 170	73%	5.82	335 / 459
tonsil	0%	0	0 / 0	91%	6.09	41 / 45
blood vessel	84%	1177.50	1125 / 1335	0%	0	0 / 0
esophagus	15%	53.19	221 / 1445	49%	2.29	90 / 183
lymph node	0%	0	0 / 0	62%	1.37	18 / 29
adipose	58%	879.42	704 / 1204	0%	0	0 / 0
lung	3%	7.04	17 / 578	53%	3.37	616 / 1155
pancreas	1%	1.61	2 / 328	43%	1.26	76 / 178
adrenal gland	0%	0	0 / 258	43%	5.48	99 / 230
heart	42%	232.59	359 / 861	0%	0	0 / 0
brain	1%	7.16	25 / 2642	38%	4.69	271 / 705
bladder	10%	16.86	2 / 21	30%	1.67	149 / 504
muscle	35%	94.78	285 / 803	0%	0	0 / 0
thymus	21%	66.38	138 / 653	8%	0.15	46 / 605
ovary	3%	7.53	6 / 180	18%	0.67	78 / 430
stomach	3%	9.28	9 / 359	16%	0.58	45 / 286
intestine	0%	0.76	4 / 966	13%	0.49	71 / 527
peripheral blood	9%	55.53	84 / 929	0%	0	0 / 0
prostate	3%	9.93	8 / 245	4%	0.11	19 / 502
kidney	0%	0	0 / 89	6%	0.32	55 / 901
liver	0%	0	0 / 226	5%	0.22	21 / 406
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007224	Biological process	smoothened signaling pathway
GO_0050772	Biological process	positive regulation of axonogenesis
GO_0060415	Biological process	muscle tissue morphogenesis
GO_0001649	Biological process	osteoblast differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_2000648	Biological process	positive regulation of stem cell proliferation
GO_0002027	Biological process	regulation of heart rate
GO_0072089	Biological process	stem cell proliferation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0060931	Biological process	sinoatrial node cell development
GO_0035115	Biological process	embryonic forelimb morphogenesis
GO_2000172	Biological process	regulation of branching morphogenesis of a nerve
GO_0060272	Biological process	embryonic skeletal joint morphogenesis
GO_0002063	Biological process	chondrocyte development
GO_0045880	Biological process	positive regulation of smoothened signaling pathway
GO_0002053	Biological process	positive regulation of mesenchymal cell proliferation
GO_0048557	Biological process	embryonic digestive tract morphogenesis
GO_0010463	Biological process	mesenchymal cell proliferation
GO_0003172	Biological process	sinoatrial valve development
GO_0003213	Biological process	cardiac right atrium morphogenesis
GO_0003163	Biological process	sinoatrial node development
GO_0001501	Biological process	skeletal system development
GO_0007399	Biological process	nervous system development
GO_0060920	Biological process	cardiac pacemaker cell differentiation
GO_0032330	Biological process	regulation of chondrocyte differentiation
GO_0060351	Biological process	cartilage development involved in endochondral bone morphogenesis
GO_0048743	Biological process	positive regulation of skeletal muscle fiber development
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding

IV. Literature review

[source]

Gene name	SHOX2
Protein name	Short stature homeobox protein 2 (Homeobox protein Og12X) (Paired-related homeobox protein SHOT) Short stature homeobox 2
Synonyms	SHOT OG12X
Description	FUNCTION: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
Accessions	O60902 ENST00000554685.2 A0A087WVB7 ENST00000441443.6 [O60902-1] ENST00000389589.8 [O60902-3] ENST00000483851.7 [O60902-2]

SHOX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review