SHOX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SHOX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SHOX2 at tissue level.

III. Associated gene sets

GO_0007224Biological processsmoothened signaling pathway
GO_0050772Biological processpositive regulation of axonogenesis
GO_0060415Biological processmuscle tissue morphogenesis
GO_0001649Biological processosteoblast differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0002027Biological processregulation of heart rate
GO_0072089Biological processstem cell proliferation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060931Biological processsinoatrial node cell development
GO_0035115Biological processembryonic forelimb morphogenesis
GO_2000172Biological processregulation of branching morphogenesis of a nerve
GO_0060272Biological processembryonic skeletal joint morphogenesis
GO_0002063Biological processchondrocyte development
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0002053Biological processpositive regulation of mesenchymal cell proliferation
GO_0048557Biological processembryonic digestive tract morphogenesis
GO_0010463Biological processmesenchymal cell proliferation
GO_0003172Biological processsinoatrial valve development
GO_0003213Biological processcardiac right atrium morphogenesis
GO_0003163Biological processsinoatrial node development
GO_0001501Biological processskeletal system development
GO_0007399Biological processnervous system development
GO_0060920Biological processcardiac pacemaker cell differentiation
GO_0032330Biological processregulation of chondrocyte differentiation
GO_0060351Biological processcartilage development involved in endochondral bone morphogenesis
GO_0048743Biological processpositive regulation of skeletal muscle fiber development
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding

IV. Literature review

[source]
Gene nameSHOX2
Protein nameShort stature homeobox protein 2 (Homeobox protein Og12X) (Paired-related homeobox protein SHOT)
Short stature homeobox 2
SynonymsSHOT
OG12X
DescriptionFUNCTION: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.

AccessionsO60902
ENST00000554685.2
A0A087WVB7
ENST00000441443.6 [O60902-1]
ENST00000389589.8 [O60902-3]
ENST00000483851.7 [O60902-2]