FOXR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FOXR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXR1 at tissue level.

III. Associated gene sets

GO_0007420Biological processbrain development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameFOXR1
Protein nameForkhead box R1 variant 2
Forkhead box R1
Forkhead box protein R1 (Forkhead box protein N5)
SynonymsFOXN5
DLNB13
DescriptionFUNCTION: Transcription factor which acts as both an activator and a repressor . Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress . Required for normal brain development (By similarity). .

AccessionsQ6PIV2
ENST00000531539.5 [Q6PIV2-2]
ENST00000317011.8 [Q6PIV2-1]
B0YJ16
ENST00000533282.1
H0YCU3