CBFB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0060216Biological processdefinitive hemopoiesis
GO_0001649Biological processosteoblast differentiation
GO_0043371Biological processnegative regulation of CD4-positive, alpha-beta T cell differentiation
GO_0030099Biological processmyeloid cell differentiation
GO_0043378Biological processpositive regulation of CD8-positive, alpha-beta T cell differentiation
GO_0000209Biological processprotein polyubiquitination
GO_0048469Biological processcell maturation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030098Biological processlymphocyte differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0016513Cellular componentcore-binding factor complex
GO_0016020Cellular componentmembrane
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0043565Molecular functionsequence-specific DNA binding

IV. Literature review

[source]
Gene nameCBFB
Protein nameCore-binding factor subunit beta
Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)
Synonyms
DescriptionFUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. .

AccessionsH3BSC0
ENST00000290858.11 [Q13951-1]
ENST00000561924.6
ENST00000565389.1
ENST00000563939.3
A0A494C0A9
Q13951
ENST00000650873.1
J3KRT0
ENST00000412916.7 [Q13951-2]
ENST00000564034.6
J3KTD8
J3KS23