LYAR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048821Biological processerythrocyte development
GO_0050766Biological processpositive regulation of phagocytosis
GO_0045087Biological processinnate immune response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045824Biological processnegative regulation of innate immune response
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0006364Biological processrRNA processing
GO_0005730Cellular componentnucleolus
GO_0001750Cellular componentphotoreceptor outer segment
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLYAR
Protein nameLy1 antibody reactive
Cell growth-regulating nucleolar protein
SynonymsPNAS-5
DescriptionFUNCTION: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs . Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression . In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA . Preferentially binds to a DNA motif containing 5'-GGTTAT-3' . Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity . In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines . Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity). .

AccessionsENST00000452476.5
ENST00000513174.1
D6RDJ1
ENST00000343470.9
Q9NX58