NSD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048298Biological processpositive regulation of isotype switching to IgA isotypes
GO_0032259Biological processmethylation
GO_0006302Biological processdouble-strand break repair
GO_0003149Biological processmembranous septum morphogenesis
GO_0070201Biological processregulation of establishment of protein localization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_2001032Biological processregulation of double-strand break repair via nonhomologous end joining
GO_0003290Biological processatrial septum secundum morphogenesis
GO_0006355Biological processregulation of DNA-templated transcription
GO_0003289Biological processatrial septum primum morphogenesis
GO_0060348Biological processbone development
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0140955Molecular functionhistone H3K36 trimethyltransferase activity
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0140954Molecular functionhistone H3K36 dimethyltransferase activity
GO_0042799Molecular functionhistone H4K20 methyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0046975Molecular functionhistone H3K36 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNSD2
Protein nameAlternative protein WHSC1
Nuclear receptor binding SET domain protein 2
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
WHSC1 protein
SynonymsTRX5
KIAA1090
WHSC1
MMSET
DescriptionFUNCTION: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) . Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro . Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) . However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes . In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation . During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). .; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). .; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) . Methylation of histone H3 at 'Lys-27' is controversial . Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) . Does not methylate histone H3 at 'Lys-27' . May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment . .

AccessionsA0A7P0P278
L0R6U5
ENST00000515806.1
ENST00000503128.5 [O96028-3]
ENST00000382888.3 [O96028-2]
D6R9V2
H0Y9U6
ENST00000677895.1
ENST00000511904.1
ENST00000678714.1 [O96028-7]
ENST00000512700.2
ENST00000507820.5
ENST00000514329.5
D6RIS1
ENST00000382892.6 [O96028-1]
ENST00000420906.6 [O96028-5]
Q05CW4
D6RFE7
A0A7I2V2S2
ENST00000353275.9 [O96028-3]
H0Y9L4
ENST00000508803.6 [O96028-1]
O96028
ENST00000509115.5
ENST00000677559.1
ENST00000382895.7 [O96028-1]
ENST00000398261.6 [O96028-3]
ENST00000312087.10 [O96028-3]
A0A7I2YQS5
ENST00000382891.9 [O96028-1]
ENST00000514045.5 [O96028-5]