Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 25% ± 7% | |
glutamatergic neuron | 9 studies | 48% ± 24% | |
epithelial cell | 9 studies | 26% ± 8% | |
astrocyte | 9 studies | 34% ± 13% | |
GABAergic neuron | 7 studies | 47% ± 20% | |
oligodendrocyte | 7 studies | 26% ± 7% | |
oligodendrocyte precursor cell | 7 studies | 32% ± 13% | |
macrophage | 7 studies | 22% ± 5% | |
retinal cone cell | 6 studies | 24% ± 7% | |
adipocyte | 6 studies | 20% ± 2% | |
dendritic cell | 6 studies | 19% ± 2% | |
neuron | 5 studies | 41% ± 15% | |
retinal ganglion cell | 5 studies | 22% ± 4% | |
microglial cell | 5 studies | 21% ± 5% | |
interneuron | 5 studies | 47% ± 21% | |
retinal rod cell | 4 studies | 28% ± 6% | |
endothelial cell of lymphatic vessel | 4 studies | 22% ± 5% | |
type I pneumocyte | 4 studies | 24% ± 8% | |
type II pneumocyte | 4 studies | 22% ± 6% | |
basal cell | 4 studies | 21% ± 4% | |
goblet cell | 4 studies | 29% ± 13% | |
B cell | 3 studies | 17% ± 1% | |
hematopoietic precursor cell | 3 studies | 26% ± 7% | |
plasma cell | 3 studies | 26% ± 7% | |
retina horizontal cell | 3 studies | 19% ± 2% | |
ciliated cell | 3 studies | 18% ± 3% | |
GABAergic amacrine cell | 3 studies | 22% ± 4% | |
ependymal cell | 3 studies | 30% ± 12% | |
alveolar macrophage | 3 studies | 22% ± 6% | |
lymphocyte | 3 studies | 22% ± 3% | |
transit amplifying cell | 3 studies | 50% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3924.52 | 1445 / 1445 | 100% | 22.15 | 183 / 183 |
brain | 100% | 4679.00 | 2641 / 2642 | 100% | 19.50 | 704 / 705 |
intestine | 100% | 5628.74 | 966 / 966 | 100% | 18.48 | 525 / 527 |
uterus | 100% | 3241.97 | 170 / 170 | 99% | 23.72 | 456 / 459 |
stomach | 100% | 3261.50 | 359 / 359 | 99% | 16.92 | 284 / 286 |
breast | 100% | 3495.89 | 459 / 459 | 99% | 17.46 | 1110 / 1118 |
lung | 100% | 4244.92 | 577 / 578 | 99% | 16.56 | 1147 / 1155 |
bladder | 100% | 3097.29 | 21 / 21 | 99% | 17.55 | 499 / 504 |
skin | 100% | 5276.96 | 1808 / 1809 | 99% | 15.19 | 466 / 472 |
ovary | 100% | 2409.13 | 180 / 180 | 99% | 14.84 | 424 / 430 |
pancreas | 100% | 2535.33 | 328 / 328 | 98% | 12.02 | 175 / 178 |
thymus | 100% | 4522.61 | 653 / 653 | 98% | 13.70 | 592 / 605 |
prostate | 100% | 3418.13 | 245 / 245 | 97% | 8.98 | 489 / 502 |
kidney | 100% | 2846.44 | 89 / 89 | 95% | 7.38 | 852 / 901 |
adrenal gland | 100% | 2678.48 | 258 / 258 | 90% | 7.32 | 208 / 230 |
liver | 99% | 1563.09 | 224 / 226 | 67% | 5.33 | 274 / 406 |
adipose | 100% | 3271.42 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.59 | 29 / 29 |
spleen | 100% | 4701.44 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 26.54 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.47 | 1 / 1 |
blood vessel | 100% | 3495.06 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2317.58 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 2342.05 | 836 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 69% | 3.90 | 55 / 80 |
peripheral blood | 65% | 4236.25 | 606 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0048298 | Biological process | positive regulation of isotype switching to IgA isotypes |
GO_0032259 | Biological process | methylation |
GO_0006302 | Biological process | double-strand break repair |
GO_0003149 | Biological process | membranous septum morphogenesis |
GO_0070201 | Biological process | regulation of establishment of protein localization |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0006338 | Biological process | chromatin remodeling |
GO_2001032 | Biological process | regulation of double-strand break repair via nonhomologous end joining |
GO_0003290 | Biological process | atrial septum secundum morphogenesis |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0003289 | Biological process | atrial septum primum morphogenesis |
GO_0060348 | Biological process | bone development |
GO_0005730 | Cellular component | nucleolus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0140955 | Molecular function | histone H3K36 trimethyltransferase activity |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0140954 | Molecular function | histone H3K36 dimethyltransferase activity |
GO_0042799 | Molecular function | histone H4K20 methyltransferase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0140938 | Molecular function | histone H3 methyltransferase activity |
GO_0046975 | Molecular function | histone H3K36 methyltransferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | NSD2 |
Protein name | Alternative protein WHSC1 Nuclear receptor binding SET domain protein 2 Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) WHSC1 protein |
Synonyms | TRX5 KIAA1090 WHSC1 MMSET |
Description | FUNCTION: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) . Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro . Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) . However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes . In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation . During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). .; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). .; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) . Methylation of histone H3 at 'Lys-27' is controversial . Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) . Does not methylate histone H3 at 'Lys-27' . May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment . . |
Accessions | A0A7P0P278 L0R6U5 ENST00000515806.1 ENST00000503128.5 [O96028-3] ENST00000382888.3 [O96028-2] D6R9V2 H0Y9U6 ENST00000677895.1 ENST00000511904.1 ENST00000678714.1 [O96028-7] ENST00000512700.2 ENST00000507820.5 ENST00000514329.5 D6RIS1 ENST00000382892.6 [O96028-1] ENST00000420906.6 [O96028-5] Q05CW4 D6RFE7 A0A7I2V2S2 ENST00000353275.9 [O96028-3] H0Y9L4 ENST00000508803.6 [O96028-1] O96028 ENST00000509115.5 ENST00000677559.1 ENST00000382895.7 [O96028-1] ENST00000398261.6 [O96028-3] ENST00000312087.10 [O96028-3] A0A7I2YQS5 ENST00000382891.9 [O96028-1] ENST00000514045.5 [O96028-5] |