PCGF2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PCGF2 at tissue level.

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0001701Biological processin utero embryonic development
GO_0048704Biological processembryonic skeletal system morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0009952Biological processanterior/posterior pattern specification
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0031519Cellular componentPcG protein complex
GO_0035102Cellular componentPRC1 complex
GO_0005654Cellular componentnucleoplasm
GO_0001739Cellular componentsex chromatin
GO_0016604Cellular componentnuclear body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePCGF2
Protein namePolycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Polycomb group RING finger protein 2 (Polycomb group ring finger 2)
SynonymsMEL18
ZNF144
RNF110
hCG_31397
DescriptionFUNCTION: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity . .

AccessionsENST00000633865.1
ENST00000618941.4
ENST00000616199.4
ENST00000610747.1
ENST00000618506.1
ENST00000611883.4
P35227
ENST00000616129.4
ENST00000632510.1
ENST00000631610.1
ENST00000632068.1
A0A087X0Y6
ENST00000620225.5
ENST00000610440.1
A0A087X259
J3KT13
ENST00000632316.1
ENST00000631566.1