Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 9 studies | 23% ± 7% | |
| endothelial cell of artery | 6 studies | 20% ± 4% | |
| vein endothelial cell | 3 studies | 23% ± 9% | |
| capillary endothelial cell | 3 studies | 22% ± 4% | |
| fibroblast | 3 studies | 20% ± 2% |
Insufficient scRNA-seq data for expression of PCGF2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 1601.39 | 1808 / 1809 | 100% | 35.41 | 472 / 472 |
| ovary | 100% | 2643.94 | 180 / 180 | 100% | 29.46 | 429 / 430 |
| prostate | 100% | 2726.10 | 245 / 245 | 100% | 25.27 | 500 / 502 |
| breast | 100% | 2555.62 | 459 / 459 | 98% | 33.61 | 1095 / 1118 |
| pancreas | 100% | 1020.76 | 328 / 328 | 98% | 23.22 | 174 / 178 |
| brain | 99% | 1185.66 | 2606 / 2642 | 99% | 24.28 | 696 / 705 |
| kidney | 100% | 3462.67 | 89 / 89 | 97% | 19.91 | 877 / 901 |
| lung | 100% | 2440.54 | 578 / 578 | 97% | 19.29 | 1121 / 1155 |
| esophagus | 100% | 1765.93 | 1445 / 1445 | 97% | 17.26 | 177 / 183 |
| bladder | 100% | 1932.24 | 21 / 21 | 97% | 23.33 | 487 / 504 |
| intestine | 100% | 1716.54 | 966 / 966 | 97% | 16.57 | 509 / 527 |
| adrenal gland | 100% | 2660.04 | 258 / 258 | 96% | 18.99 | 221 / 230 |
| uterus | 100% | 3034.80 | 170 / 170 | 96% | 21.18 | 440 / 459 |
| thymus | 100% | 3169.73 | 653 / 653 | 95% | 27.47 | 577 / 605 |
| stomach | 100% | 1480.12 | 359 / 359 | 94% | 15.23 | 268 / 286 |
| liver | 76% | 454.50 | 172 / 226 | 51% | 5.79 | 208 / 406 |
| adipose | 100% | 2257.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2144.27 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 25.61 | 80 / 80 |
| spleen | 100% | 1956.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 54.33 | 1 / 1 |
| heart | 100% | 1597.10 | 860 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 11.44 | 43 / 45 |
| muscle | 66% | 319.25 | 528 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 19% | 347.99 | 176 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 1.23 | 3 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0097190 | Biological process | apoptotic signaling pathway |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0048704 | Biological process | embryonic skeletal system morphogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_2001234 | Biological process | negative regulation of apoptotic signaling pathway |
| GO_0009952 | Biological process | anterior/posterior pattern specification |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0031519 | Cellular component | PcG protein complex |
| GO_0035102 | Cellular component | PRC1 complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0001739 | Cellular component | sex chromatin |
| GO_0016604 | Cellular component | nuclear body |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_1990841 | Molecular function | promoter-specific chromatin binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PCGF2 |
| Protein name | Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) Polycomb group RING finger protein 2 (Polycomb group ring finger 2) |
| Synonyms | MEL18 ZNF144 RNF110 hCG_31397 |
| Description | FUNCTION: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity . . |
| Accessions | ENST00000633865.1 ENST00000618941.4 ENST00000616199.4 ENST00000610747.1 ENST00000618506.1 ENST00000611883.4 P35227 ENST00000616129.4 ENST00000632510.1 ENST00000631610.1 ENST00000632068.1 A0A087X0Y6 ENST00000620225.5 ENST00000610440.1 A0A087X259 J3KT13 ENST00000632316.1 ENST00000631566.1 |
