OTUD7B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0001701Biological processin utero embryonic development
GO_0002385Biological processmucosal immune response
GO_0071947Biological processprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0002250Biological processadaptive immune response
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0006508Biological processproteolysis
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0035871Biological processprotein K11-linked deubiquitination
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0008270Molecular functionzinc ion binding
GO_1990380Molecular functionK48-linked deubiquitinase activity
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOTUD7B
Protein nameOTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
SynonymsZA20D1
RP11-212K13.2-003
DescriptionFUNCTION: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B . Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR . Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains . Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure . Hydrolyzes both linear and branched forms of polyubiquitin. .

AccessionsQ5SZ59
ENST00000417191.2
Q6GQQ9
ENST00000581312.6 [Q6GQQ9-1]