SAMD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0051260Biological processprotein homooligomerization
GO_0034439Biological processlipoprotein lipid oxidation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090308Biological processregulation of DNA methylation-dependent heterochromatin formation
GO_0090077Biological processfoam cell differentiation
GO_0005615Cellular componentextracellular space
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0030169Molecular functionlow-density lipoprotein particle binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameSAMD1
Protein nameSterile alpha motif domain containing 1
Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin)
Synonyms
DescriptionFUNCTION: Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor . Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs . Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell . .

AccessionsENST00000269724.5
Q6SPF0
F8WDT5
ENST00000533683.7
E9PIW9
ENST00000673075.2